Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance
Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance
复制标题
拮抗受体的表观遗传调控赋予稻瘟病抗性和产量平衡。
DOI：
10.1126/science.aai8898
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发表时间：
2017-03-03
期刊：
影响因子：
56.9
通讯作者：
He, Zuhua
中科院分区：
文献类型：
--
作者：
Deng, Yiwen;Zhai, Keran;He, Zuhua
作物育种的目的是在抗病性和产量之间取得平衡；然而，单个抗性基因(R)可能导致抗性分解，R基因的金字塔化可能影响生长适合度。在这里，我们报道了水稻Pigm位点包含一个编码核苷酸结合的富含亮氨酸重复序列（NLR）受体的基因簇，该受体赋予对真菌Magnaporthe oryzae的持久抗性而不影响产量。在这些NLR受体中，PigmR赋予广谱抗性，而PigmS竞争性地减弱PigmR同二聚体以抑制抗性。PigmS的表达以及由此介导的抗性受到严格的表观遗传调控。PigmS增加种子产量以抵消PigmR带来的产量成本。因此，我们的研究揭示了通过配对拮抗NLR受体的表观遗传调控来平衡高抗病和高产的机制，为培育优良作物品种提供了工具。
Crop breeding aims to balance disease resistance with yield; however, single resistance (R) genes can lead to resistance breakdown, and R gene pyramiding may affect growth fitness. Here we report that the rice Pigm locus contains a cluster of genes encoding nucleotide-binding leucine-rich repeat (NLR) receptors that confer durable resistance to the fungus Magnaporthe oryzae without yield penalty. Among these NLR receptors, PigmR confers broad-spectrum resistance, whereas PigmS competitively attenuates PigmR homodimerization to suppress resistance. PigmS expression, and thus PigmR-mediated resistance, are subjected to tight epigenetic regulation. PigmS increases seed production to counteract the yield cost induced by PigmR. Therefore, our study reveals a mechanism balancing high disease resistance and yield through epigenetic regulation of paired antagonistic NLR receptors, providing a tool to develop elite crop varieties.