Insular cortical and amygdaloid fibers are in contact with posterolateral hypothalamic neurons projecting to the nucleus of the solitary tract in the rat
Insular cortical and amygdaloid fibers are in contact with posterolateral hypothalamic neurons projecting to the nucleus of the solitary tract in the rat
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DOI：
10.1016/j.brainres.2005.11.040
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发表时间：
2006-01
期刊：
影响因子：
2.9
通讯作者：
T. Tsumori;S. Yokota;Toshiro Kishi;Yi Qin;T. Oka;Y. Yasui
中科院分区：
文献类型：
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作者：
T. Tsumori;S. Yokota;Toshiro Kishi;Yi Qin;T. Oka;Y. Yasui
将霍乱毒素B亚单位（CT B）注入大鼠孤束核（NST），生物素葡聚糖胺（BDA）注入大鼠岛叶皮质（IC）或杏仁中央核（ACe），CTb标记神经元和BDA标记轴突终末在下丘脑后外侧区（PLH）有明显的重叠分布注射部位同侧的丘脑底核内侧区域。在电镜水平上，IC终末与NST投射的PLH神经元的树突和树突棘形成不对称的突触接触，而ACe终末与NST投射的PLH神经元的胞体和树突形成对称的突触接触。目前的数据表明，从IC和ACe的输出信号可能会产生兴奋和抑制的影响，分别对PLH神经元的项目，NST的心血管功能的调节。
After ipsilateral injections of cholera toxin B subunit (CTb) into the nucleus of the solitary tract (NST) and biotinylated dextran amine (BDA) into the insular cortex (IC) or into the central amygdaloid nucleus (ACe) in the rat, the prominent overlapping distribution of CTb-labeled neurons and BDA-labeled axon terminals was found in the posterolateral hypothalamus (PLH) region just medial to the subthalamic nucleus ipsilateral to the injection sites. At the electron microscopic level, the IC terminals formed asymmetrical synaptic contacts with dendrites and dendritic spines of the NST-projecting PLH neurons, whereas the ACe terminals formed symmetrical synaptic contacts with somata and dendrites of the NST-projecting PLH neurons. The present data suggest that output signals from the IC and ACe may exert excitatory and inhibitory influences, respectively, upon the PLH neurons that project to the NST for regulating cardiovascular functions.