Eph and ephrin signaling in mammary gland morphogenesis and cancer
Eph and ephrin signaling in mammary gland morphogenesis and cancer
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DOI：
10.1023/b:jomg.0000017433.83226.22
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发表时间：
2003-10-01
影响因子：
2.5
通讯作者：
Ziemiecki, A
中科院分区：
文献类型：
--
作者：
Andres, AC;Ziemiecki, A
Eph家族的受体酪氨酸激酶和它们的膜结合配体，肝配蛋白，在胚胎发育过程中的模式形成中发挥核心作用，并且有越来越多的证据表明，它们也有助于控制成人的组织动力学。乳腺是发生在成人中的形态发生过程的范例，因为腺体主要在出生后发育，并且根据功能需求进行连续的周期性重塑。因此，模式形成和功能器官结构的建立是乳腺生命周期中的永恒主题。在本文中，我们总结了实验证据，并讨论了可能的机制，Ephs和ephrins调节乳腺上皮细胞的粘附，通信和迁移。此外，我们推测它们对正常乳腺发育，功能和癌变的影响的不同方面。
The Eph family of receptor tyrosine kinases and their membrane-bound ligands, the ephrins, play a central role in pattern formation during embryonic development and there is growing evidence that they are also instrumental in the control of tissue dynamics in the adult. The mammary gland is a paradigm for morphogenic processes occurring in the adult, since the gland develops predominantly postnatally and is subjected to continuous cyclic remodeling according to functional demands. Thus, pattern formation and the establishment of a functional organ structure are permanent themes in the mammary gland life cycle. In this paper we summarize the experimental evidence and discuss possible mechanisms by which Ephs and ephrins are modulating mammary epithelial cell adhesion, communication, and migration. Furthermore, we speculate on the different aspects of their influence on normal mammary gland development, function, and carcinogenesis.