Vitamin D Supplementation Does Not Increase Immunogenicity of Seasonal Influenza Vaccine in HIV-Infected Adults
Vitamin D Supplementation Does Not Increase Immunogenicity of Seasonal Influenza Vaccine in HIV-Infected Adults
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DOI：
10.1310/hct1205-275
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发表时间：
2011-09-01
影响因子：
--
通讯作者：
Thorne, Anona
中科院分区：
文献类型：
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作者：
Cooper, Curtis;Thorne, Anona
利用2008-2009年流感季节进行的一项3期随机试验的数据，评估了维生素Don流感疫苗对艾滋病毒免疫原性的影响。33%的参与者在基线时补充维生素D。使用维生素D均不能预测3种疫苗株的血清转化和血清保护。在艾滋病毒阳性人群中，没有证据表明补充维生素D可以改善流感疫苗的免疫原性。
The influence of vitamin Don influenza vaccine immunogenicity in HIV was assessed using data from a phase 3, randomized trial conducted during the 2008-2009 influenza season. Thirty-three percent of participants were on supplemental vitamin D at baseline. Neither seroconversion nor seroprotection were predicted by vitamin D use for any of the 3 vaccine strains. There is no evidence of improved influenza vaccine immunogenicity with vitamin D supplementation in this HIV-positive population.