IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia.
IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia.
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DOI：
10.3109/10641955.2015.1032054
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发表时间：
2015
影响因子：
1.5
通讯作者：
LaMarca B
中科院分区：
文献类型：
--
作者：
Harmon A;Cornelius D;Amaral L;Paige A;Herse F;Ibrahim T;Wallukat G;Faulkner J;Moseley J;Dechend R;LaMarca B
使用先兆子痫的子宫灌注压降低（RUPP）大鼠模型来确定添加的白细胞介素-10（IL-10）对响应于胎盘缺血的TCRP和高血压的影响，以及这些抗炎因子的减少如何介导先兆子痫的病理生理学。于妊娠第14天经腹腔植入渗透性微泵，注入IL-10（2.5ng/kg/d），同时行RUPP手术。在RUPP大鼠中，IL-10降低平均动脉压（p<0.001），减少CD 4 + T细胞（p = 0.044），同时增加T细胞（p = 0.043），这导致较低的IL-6和TNF-α（p = 0.008和p = 0.003），减少AT 1-AA产生（p<0.001），并降低氧化应激（p = 0.029）。这些数据表明，IL-10补充剂增加了TcB，并有助于平衡先兆子痫期间观察到的改变的免疫系统。
The reduced uterine perfusion pressure (RUPP) rat model of preeclampsia was used to determine the effects of added interleukin-10 (IL-10) on Tregs and hypertension in response to placental ischemia and how the decrease in these anti-inflammatory factors mediates the pathophysiology of preeclampsia. IL-10 (2.5 ng/kg/d) was infused via osmotic mini-pump implanted intraperitoneally on day 14 of gestation and, at the same time, the RUPP procedure was performed. IL-10 reduced mean arterial pressure (p<0.001), decreased CD4+ T cells (p = 0.044), while increasing Tregs (p = 0.043) which led to lower IL-6 and TNF-α (p = 0.008 and p = 0.003), reduced AT1-AA production (p<0.001), and decreased oxidative stress (p = 0.029) in RUPP rats. These data indicate that IL-10 supplementation increases Tregs and helps to balance the altered immune system seen during preeclampsia.