SECONDARY EXTERNAL-BEAM RADIOTHERAPY AND HYPERTHERMIA FOR LOCAL RECURRENCE AFTER 125-IODINE IMPLANTATION IN ADENOCARCINOMA OF THE PROSTATE
SECONDARY EXTERNAL-BEAM RADIOTHERAPY AND HYPERTHERMIA FOR LOCAL RECURRENCE AFTER 125-IODINE IMPLANTATION IN ADENOCARCINOMA OF THE PROSTATE
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DOI：
10.1016/0360-3016(91)90068-f
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发表时间：
1991-03-01
影响因子：
7
通讯作者：
BAGSHAW, MA
中科院分区：
文献类型：
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作者：
KAPLAN, I;KAPP, DS;BAGSHAW, MA
在斯坦福大学，6名患者在125碘植入后局部复发后接受了一个疗程的外部放疗。 六名患者中的四名还接受了伴随的体温过高。 四名患者最初在局部复发时接受激素治疗，随后接受外照射放疗伴或不伴高热。 使用环形相控阵辐射电磁系统非侵入性地诱导热疗。 治疗耐受性良好，没有患者出现严重的直肠或膀胱并发症。 3例患者无疾病; 1例患者发生基于活检的局部区域复发; 1例膀胱复发，接受膀胱切除术治疗，随后死于转移性疾病; 1例患者死于假定的转移性疾病。 外照射结合热疗可以安全地治疗125碘植入后局部复发的前列腺癌。
At Stanford, six patients underwent a course of external radiotherapy after local recurrence following 125-iodine implantation. Four of the six patients also received concomitant hyperthermia. Four patients were initially managed with hormonal manipulation at time of local relapse and subsequently received external beam radiotherapy with or without hyperthermia. The hyperthermia was non-invasively induced using an annular phased array radiative electromagnetic system. Treatment was well tolerated, and none of the patients experienced severe rectal or bladder complications. Three patients are free from disease; one patient experienced local-regional recurrence based on biopsy; one recurred in the bladder, was treated with cystoprostatectomy and subsequently succumbed to metastatic disease; and one patient died of presumed metastatic disease. External-beam irradiation with concurrent hyperthermia can be safely delivered to treat locally recurrent prostatic carcinoma after 125-iodine implantation.