Does human primary motor cortex represent sequences of finger movements?
Does human primary motor cortex represent sequences of finger movements?
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人类初级运动皮层是否代表手指运动的序列？
DOI：
10.1101/157438
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Diedrichsen Joerrn
中科院分区：
文献类型：
--
作者：
Yokoi Atsushi;Arbuckle Spencer A.;Diedrichsen Joerrn
人类初级运动皮质(M1)是产生灵巧手部动作的基本结构。虽然不同的神经元亚群在单指运动过程中被激活，但尚不清楚M1是否也代表多指运动序列。使用新的多变量fMRI分析技术，我们在这里表明，即使在5天的密集练习之后，也很少或没有证据表明M1中存在真实的序列表示。相反，M1中序列的活动模式可以通过与构成单个手指运动相关的模式的线性组合来解释，手指上的最大权重做出序列的第一个反应。这些结果表明，M1只代表单个手指的运动，但在序列开始时接受更多的输入。相比之下，运动前区和顶区不同序列之间的可靠差异不能用食指的强大权重来解释，这支持了这些区域展示了序列的真实代表的观点。
Human primary motor cortex (M1) is an essential structure for the production of dexterous hand movements. While distinct sub-populations of neurons are activated during single finger movements, it remains unknown whether M1 also represents sequences of multiple finger movements. Using novel multivariate fMRI analysis techniques, we show here that even after 5 days of intense practice there was little or no evidence for a true sequence representation in M1. Rather, the activity patterns for sequences in M1 could be explained by linear combination of patterns associated with the constituent individual finger movements, with the strongest weight on the finger making the first response of the sequence. These results suggest that M1 only represents single finger movements, but receives increased input at the start of a sequence. In contrast, the reliable differences between different sequences in premotor and parietal areas could not be explained by a strong weighting of the first finger, supporting the view that these regions exhibit a true representation of sequences.