Human/nonhuman primate AC-PC ratio-Considerations for translational brain measurements
Human/nonhuman primate AC-PC ratio-Considerations for translational brain measurements
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DOI：
10.1016/j.jneumeth.2010.12.023
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发表时间：
2011-03-15
影响因子：
3
通讯作者：
Bankiewicz, Krystof S.
中科院分区：
文献类型：
--
作者：
Fiandaca, Massimo S.;Salegio, Ernesto Aguilar;Bankiewicz, Krystof S.
本比较磁共振成像（MRI）分析在选定的人类和非人灵长类动物（NHPs）群体中评估AC-PC（前联合与后联合）距离测量的比率。了解灵长类物种之间这种比率的基础，可以更准确地将NHP立体定向靶向测量翻译到即将进行的人体试验中。在中矢状面评估成人[n = 21]、幼年和成年NHPs （Macaca fascicularis [n = 40]和mulatto Macaca [n = 32]）的MRI数据集，以获得每个被检查对象的AC-PC距离测量值。两名训练有素的评估员，对彼此的结果不知情，对每个受试者的交流- pc长度进行了三次单独的测量。每个观察者对整个数据集进行测量[n = 93]，然后再重复两次测量。在进行后续测量时，以前的数据集测量无法进行审查。观察者之间和观察者内部的变量没有统计学意义。在我们的人类和NHP组的AC-PC测量中发现最小的种内变异。然而，我们发现了显著的物种间差异，人类和NHP之间的差异更大，而NHP群体之间的差异较小。回归分析证实，在我们的研究组中，主要基于物种的交流- pc距离具有很强的线性关系。人类/NHP的AC-PC比值在2.1 - 2.3之间变化。我们的结论是，本研究中描述的NHPs和人类大脑测量的尺度差异可以在未来的人类临床试验中改进立体定向靶向坐标的翻译，这可能会提高疗效和安全性。(C) 2010 Elsevier B.V.版权所有
This comparative magnetic resonance imaging (MRI) analysis evaluated the ratio of AC-PC (anterior commissure to posterior commissure) distance measures in selected groups of humans and nonhuman primates (NHPs). An understanding of the basis of this ratio between primate species may allow more accurate translation of NHP stereotactic targeting measurements to upcoming human trials. MRI datasets of adult humans [n = 21], and juvenile and adult NHPs (Macaca fascicularis [n = 40], and Macaca mulatto [n = 32]), were evaluated in a mid-sagittal plane to obtain the AC-PC distance measure for each examined subject. Two trained evaluators, blinded to each other's results, carried out three separate measurements of the AC-PC length for each subject. Each observer carried out measurements of the entire dataset [n = 93] before repeating the measurements two additional times. Previous dataset measures were not available for review at the time of subsequent measures. Inter- and intra-observer variabilities were not statistically significant. Minimal intraspecies variation was found in the AC-PC measurement of our human and NHP groups. We found significant interspecies differences, however, more between humans and NHPs, and less between the NHP groups. Regression analysis confirms the strong linear relationship of AC-PC distance based primarily on species in our study groups. Human/NHP AC-PC ratios varied between 2.1 and 2.3 based on the compared NHP species groups. We conclude that the scale differences in brain measurements between NHPs and humans described in this study allows improved translation of stereotactic targeting coordinates in future human clinical trials, which may lead to improved efficacy and safety. (C) 2010 Elsevier B.V. All rights reserved.