Gold nanoparticles-based nanoconjugates for enhanced enzyme cascade and glucose sensing.
Gold nanoparticles-based nanoconjugates for enhanced enzyme cascade and glucose sensing.
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DOI：
10.1039/c2an35900f
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发表时间：
2012-08
期刊：
影响因子：
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通讯作者：
Dongdong Zeng;Weijie Luo;Jiang Li;Huajie Liu;Hongwei Ma;Qing Huang;C. Fan
中科院分区：
文献类型：
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作者：
Dongdong Zeng;Weijie Luo;Jiang Li;Huajie Liu;Hongwei Ma;Qing Huang;C. Fan
我们将金纳米颗粒与辣根过氧化物酶（HRP）偶联，组装催化纳米复合物（HRP-AuNPs）用于葡萄糖检测。我们发现，HRP/金纳米粒子的适当的混合比例可以显着提高级联反应的催化活性，从酶之间的空间耦合增加所产生的效果。这种基于金纳米颗粒的纳米缀合物被证明是有前途的葡萄糖纳米传感器。
We have coupled gold nanoparticles with horseradish peroxidase (HRP) to assemble catalytic nanoconjugates (HRP-AuNPs) for glucose detection. We found that a proper mixing ratio of HRP/AuNPs can significantly improve catalytic activity for the cascade reaction, an effect arising from increased spatial coupling between enzymes. Such gold nanoparticle-based nanoconjugates are shown to be promising nanosensors for glucose.