Women with sleep apnea have lower levels of sex hormones.
Women with sleep apnea have lower levels of sex hormones.
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DOI：
10.1007/s11325-003-0025-8
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发表时间：
2003-03-01
期刊：
影响因子：
--
通讯作者：
Strohl, Kingman P
中科院分区：
文献类型：
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作者：
Netzer, Nikolaus C;Eliasson, Arn H;Strohl, Kingman P
背景：性激素水平低，尤其是黄体酮，被怀疑是睡眠呼吸障碍 (SDB) 的危险因素。目的：检验具有临床意义的 SDB 的女性中孕酮、雌二醇和 17-OH 黄体酮血清水平较低的假设。设计：方便临床队列。地点：大学医院睡眠实验室。方法：我们连续调查了 53 名女性的睡眠和呼吸参数以及性激素血清水平。 （24 至 72 岁）正在接受白天嗜睡症状的评估。通过特定的放射免疫测定和荧光免疫测定对过夜多导睡眠图后采集的血液样本进行激素状态分析。 结果：在整个队列中，考虑到年龄和周期时间或绝经后状态，呼吸暂停低通气指数 (AHI) 大于 10/小时睡眠的患者的 17-OH 孕酮、黄体酮和雌二醇水平显着低于睡眠呼吸暂停低通气指数 (AHI) 的患者。 AHI 小于 10。 结论：我们得出结论，女性性激素的减少与白天嗜睡的女性 SDB 的可能性增加有关。
BACKGROUND: Low levels of sex hormones, especially progesterone, are suspected as a risk factor for sleep-disordered breathing (SDB).OBJECTIVE: To test the hypothesis that serum levels of progesterone, estradiol, and 17-OH progesterone are lower in those women with clinically significant SDB.DESIGN: Clinical cohort of convenience.SETTING: University Hospital Sleep Laboratory.METHODS: We investigated sleep and breathing parameters and serum levels of sex hormones in 53 consecutive women (ages 24 to 72 years) being evaluated for symptoms of daytime sleepiness. Analysis of hormonal status by specific radioimmunoassays and fluorescence immunoassays was done from blood samples taken after an overnight polysomnography.RESULTS: Across the cohort, taking account of age and cycle time or postmenopausal status, those with an apnea-hypopnea index (AHI) greater than 10/hrs of sleep had significantly lower levels of 17-OH progesterone, progesterone, and estradiol than those with an AHI less than 10.CONCLUSION: We conclude that reductions in female sex hormones are associated with an increased probability of SDB in women with daytime sleepiness.