Epidemiology of Cardiovascular Malformations among Newborns in Monchegorsk (North-West Russia): a Register-Based Study.
Epidemiology of Cardiovascular Malformations among Newborns in Monchegorsk (North-West Russia): a Register-Based Study.
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DOI：
10.4081/jphr.2014.270
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发表时间：
2014-07-02
影响因子：
2.3
通讯作者：
Vaktskjold A
中科院分区：
文献类型：
--
作者：
Postoev VA;Talykova LV;Vaktskjold A
心血管畸形（CVM）是最常见的出生缺陷之一。关于俄罗斯的流行、分布和生存情况的了解有限。我们研究的目的是评估蒙切戈尔斯克（俄罗斯摩尔曼斯克州）新生儿围产期 CVM 患病率、结构和危险因素，以及 1973 年至 2008 年期间受影响新生儿的死亡率。对科拉和摩尔曼斯克县出生登记处数据进行的基于登记的研究。该研究包括 28,511 名新生儿。登记的围产期患病率为每 1000 名新生儿 3.0 例，其中间隔缺损最为常见。死产中 CVM 的患病率是活产的 20 倍，患有 CVM 的活产婴儿中有三分之一在出生后第一周内死亡。 CVM 围产儿死亡率为每 1000 名新生儿 442 人。该指标随着时间的推移而下降。患有 CVM 的新生儿的母亲在其病史中死产的可能性要高出十倍。母亲怀孕期间吸烟与 CVM 之间的调整后比值比为 4.09 [95% 置信区间：1.75-9.53]。围产期诊断患病率相对较低。母亲之前的死产与出生时患有 CVM 高度相关。在吸烟的母亲中也观察到调整后的风险升高。围产期存活率随着时间的推移而增加，但不同类型的 CVM 之间存在很大差异。心血管畸形是最常见的出生缺陷之一。它被认为是一个重要的公共卫生问题，因为这些畸形是发达国家婴儿死亡的主要原因。需要对患病率和围产期生存率进行精确估计，以便为此类新生儿组织和规划医疗保健。我们的研究是俄罗斯联邦基于人口出生登记数据的第一份报告。
Cardiovascular malformations (CVM) are one of the most prevalent groups of birth defects. Knowledge about the prevalence, distribution and survival in Russia has been limited. The aim of our study was to assess the perinatal prevalence, structure and risk factors for CVM among newborns in Monchegorsk (Murmansk Oblast, Russia) and the mortality among the affected newborns in the period 1973-2008. A register-based study on data from the Kola and Murmansk County Birth Registers. The study included 28,511 births. The registered perinatal prevalence was 3.0 per 1000 new-borns, with septal defects as the most prevalent. CVM was twenty times more prevalent among stillborn than live born, and one-third of the live born with a CVM died during the first week of life. The perinatal mortality rate with CVM was 442 per 1000 newborns. This indicator decreased over time. The mothers of newborns with a CVM were ten times more likely to have stillbirth in their anamnesis. The adjusted odds ratio between maternal smoking during pregnancy and CVM was 4.09 [95% confidence interval: 1.75-9.53]. The diagnosed perinatal prevalence was relatively low. A previous stillbirth by the mother was highly associated with being born with a CVM. An adjusted elevated risk was also observed among smoking mothers. Perinatal survival increased over time, but varied to a large extent between the different types of CVM. Cardiovascular malformation is one of the most common groups of birth defects. It is considered an important public health issue, as these malformations are the main cause of infant deaths in developed countries. Precise estimates about the prevalence and perinatal survival are needed to organise and plan health care for such newborns. Our study is the first report from the Russian Federation based on data from population-based birth registers.