Basic mechanisms in intracranial large-artery atherosclerosis: advances and challenges.
Basic mechanisms in intracranial large-artery atherosclerosis: advances and challenges.
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DOI：
10.1159/000089359
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Alvarez-Sabin, Jose
中科院分区：
文献类型：
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作者：
Arenillas, Juan F;Alvarez-Sabin, Jose
颅内大动脉粥样硬化是世界范围内缺血性脑卒中的主要原因。尽管有抗血栓治疗，但受此病影响的患者仍有复发性缺血性事件的高风险。进展和更大程度的颅内动脉粥样硬化意味着更高的复发风险。本组在有症状的颅内大动脉粥样硬化患者中进行的研究表明：(1)c反应蛋白预测其进展和复发，提示炎症可能在该疾病中起有害作用；(2)高水平的抗血管生成内皮抑素也与进行性和复发性颅内动脉粥样硬化相关，这可能支持在这组患者中血管生成的有益作用；(3)脂蛋白(a)浓度升高和糖尿病是颅内狭窄发生率较高的患者的特征。
Intracranial large-artery atherosclerosis is a major cause of ischemic stroke worldwide. Patients affected by this disease are at a high risk of suffering recurrent ischemic events despite antithrombotic therapy. Progression and a greater extent of intracranial atherosclerosis imply a higher risk for recurrence. Studies performed by our group in patients with symptomatic intracranial large-artery atherosclerosis have shown that: (1) C-reactive protein predicts its progression and recurrence, suggesting that inflammation may play a deleterious role in this condition; (2) a high level of the anti-angiogenic endostatin is also associated with a progressive and recurrent intracranial atherosclerosis, which might support a beneficial role for angiogenesis in this group of patients; and (3) elevated lipoprotein(a) concentration and diabetes mellitus characterize those patients with a higher number of intracranial stenoses.