Extracellular Nucleic Acids in Maternal Circulation as Potential Biomarkers for Placental Insufficiency
Extracellular Nucleic Acids in Maternal Circulation as Potential Biomarkers for Placental Insufficiency
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DOI：
10.1089/dna.2011.1530
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发表时间：
2012-07-01
影响因子：
3.1
通讯作者：
Hromadnikova, Ilona
中科院分区：
文献类型：
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作者：
Hromadnikova, Ilona
由于胎盘在正常胎盘发育过程中不断重塑，因此在正常妊娠过程中，可以在母体循环中检测到胎儿和胎盘来源的细胞外核酸，这些核酸被包装到滋养层衍生的凋亡小体或脱落的合体滋养层微粒中。胎盘功能不全相关的妊娠并发症已被证明与胎盘滋养层细胞凋亡过多和胎盘碎片脱落有关。回顾了该领域的最新进展，重点是特定分子生物标志物的诊断潜力及其在当前使用的胎盘功能不全相关妊娠并发症的预测和诊断算法中的最终实施。
Since the placenta is being continuously remodeled during normal placental development, extracellular nucleic acids of both fetal and placental origin, packed into either trophoblast-derived apoptotic bodies or shedding syncytiotrophoblast microparticles, may be detected in maternal circulation during the course of normal gestation. Placental-insufficiency-related pregnancy complications have been shown to be associated with excessive placental trophoblast apoptosis and shedding of placenta debris. Recent advances in the field are reviewed with a focus on the diagnostic potential of particular molecular biomarkers and their eventual implementation in the currently used predictive and diagnostic algorithms for placental-insufficiency-related pregnancy complications.