Checking hazard regression models using pseudo-observations.

Checking hazard regression models using pseudo-observations.
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DOI:
10.1002/sim.3401
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发表时间:
2008-11-10
影响因子:
2
通讯作者:
Andersen, Per Kragh
Andersen, Per Kragh
中科院分区:
医学3区
文献类型:
--
作者:
Perme, Maja Pohar;Andersen, Per Kragh

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模型诊断的图形方法是模型拟合过程的重要组成部分。然而,在生存分析中,绘图总是受到删失的存在。虽然特定于模型的解决方案确实存在并且通常使用,但我们提出了一种更通用的方法,该方法使用相同的框架覆盖所有模型。伪观测值使我们能够计算每个个体在每个时间点的残差,而不考虑删失,并提供了同时检查考克斯和加性模型的所有假设的方法。我们介绍的方法,以及多个协变量的情况下,并补充他们与相应的拟合优度检验。模拟以及真实的数据的例子说明的方法。版权所有© 2008约翰威利父子有限公司.
Graphical methods for model diagnostics are an essential part of the model fitting procedure. However, in survival analysis, the plotting is always hampered by the presence of censoring. Although model specific solutions do exist and are commonly used, we present a more general approach that covers all the models using the same framework. The pseudo-observations enable us to calculate residuals for each individual at each time point regardless of censoring and provide methods for simultaneously checking all the assumptions of both the Cox and the additive model. We introduce methods for single as well as multiple covariate cases and complement them with corresponding goodness-of-fit tests. The methods are illustrated on simulated as well as real data examples. Copyright © 2008 John Wiley & Sons, Ltd.
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