A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles
A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles
复制标题
DOI：
10.1523/jneurosci.23-08-03483.2003
复制
发表时间：
2003-04-15
影响因子：
5.3
通讯作者：
Wang, ZX
中科院分区：
文献类型：
--
作者：
Aragona, BJ;Liu, Y;Wang, ZX
虽然伏隔核多巴胺(DA)在奖赏学习中的作用已经被广泛研究，但很少有研究涉及它在学习社会相关信息中的作用。在这里，我们研究了NAcc DA在一夫一妻制草原田鼠(Microtus Orchrogaster)的社会依恋中的作用。我们首先证明了DA对雄性草原田鼠的社会依恋的形成是必要的，因为氟哌啶醇的给药阻止了这种作用，而阿朴吗啡则诱导了伴侣偏爱的形成。然后，我们首次描述了田鼠NAcc中DA的神经解剖学和组织内容物，交配似乎导致DA周转增加33%。我们还发现，将氟哌啶醇直接注入NAcc可阻断交配和阿朴吗啡诱导的伴侣偏好。此外，在没有交配的情况下，给NAcc注射阿朴吗啡，但不给尾壳核注射阿朴吗啡，可以诱导配偶偏爱。总之，我们的数据支持这样的假设，即NAcc DA对雄性草原田鼠成对键的形成至关重要。
Although the role of nucleus accumbens (NAcc) dopamine (DA) in reward learning has been extensively studied, few investigations have addressed its involvement in learning socially relevant information. Here, we have examined the involvement of NAcc DA in social attachment of the "monogamous" prairie vole ( Microtus orchrogaster). We first demonstrated that DA is necessary for the formation of social attachment in male prairie voles, because administration of haloperidol blocked, whereas apomorphine induced, partner-preference formation. We then provided the first descriptions of DA neuroanatomy and tissue content in vole NAcc, and mating appeared to induce a 33% increase in DA turnover. We also showed that administration of haloperidol directly into the NAcc blocked partner preferences induced by mating and apomorphine. In addition, administration of apomorphine into the NAcc but not the caudate putamen induced partner preferences in the absence of mating. Together, our data support the hypothesis that NAcc DA is critical for pair-bond formation in male prairie voles.