The hormonal and local regulation of bone formation.
The hormonal and local regulation of bone formation.
复制标题
DOI：
10.1210/edrv-4-1-62
复制
发表时间：
1983
影响因子：
20.3
通讯作者：
E. Canalis
中科院分区：
文献类型：
--
作者：
E. Canalis
在过去的几年里，关于激素、生长因子和局部调节因子对骨形成的控制已经获得了相当多的知识。然而，这些药物对骨的作用是复杂的、直接的和间接的，我们对骨形成的规律的了解还不完全。这也是由于激素的体外或直接效应与其体内效应之间的差异，这可能是由间接机制介导的。骨形成研究中的另一个问题是缺乏合适的体外模型。最近，研究培养骨合成DNA和胶原的方法已经发展起来，以检测对骨细胞复制和基质形成的影响。这些方法使得研究激素对骨生长的这两个重要参数的直接影响成为可能，这是近年来几个实验室做出的巨大努力。
Introduction DURING the past several years, a considerable amount of knowledge has been obtained about the control of bone formation by hormones, growth factors, and local regulatory factors. However, these agents have complex, direct and indirect effects on bone, and our understanding of the regulation of bone formation is still incomplete. This is also due to discrepancies between the in vitro or direct effects of hormones and their in vivo effects, which may be mediated by indirect mechanisms. Another problem in the study of bone formation has been related to a paucity in the development of appropriate in vitro models. Recently, methods have been developed to study the synthesis of DNA and collagen by cultured bones in order to examine effects on bone cell replication and matrix formation. These methods have allowed the study of the direct effects of hormones on these two important parameters of bone growth and this has been a large effort of several laboratories in recent years.