3D Co-doped Ni-based conductive MOFs modified electrochemical sensor for highly sensitive detection of L-tryptophan
3D Co-doped Ni-based conductive MOFs modified electrochemical sensor for highly sensitive detection of L-tryptophan
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DOI：
10.1016/j.talanta.2022.123596
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发表时间：
2022-05-28
期刊：
影响因子：
6.1
通讯作者：
Yu, Guangxia
中科院分区：
文献类型：
--
作者：
Huang, Wei;Chen, Yao;Yu, Guangxia
l -色氨酸（Trp）是人体必需的氨基酸，在许多代谢功能中起着至关重要的作用。色氨酸水平可用于诊断各种代谢紊乱以及与这些疾病相关的症状。本文基于三维牡丹状双金属导电MOFs （Co-Ni-MOFs）制备了一种新型、简单、灵敏的电化学检测色氨酸的传感器。采用简单的一锅水热法制备了双金属导电MOFs。由于Ni2+和Co2+离子的协同作用，双金属Co-Ni-MOFs具有良好的电导率、较大的有效表面积和对Trp氧化的高电催化活性等电化学性能。因此，co - ni - mofs修饰电极对Trp的检测限为8.7 nmol L-1 (S/N = 3)，线性范围为10 ~ 300 μ mol L-1。此外，所制备的传感器还具有高选择性、长期稳定性和重复性。此外，该传感器已成功应用于镉中毒小鼠血浆中色氨酸水平的测定。
L-tryptophan (Trp) is an essential amino acid for humans and plays crucial roles in many metabolic functions. Trp levels can be used for diagnosing different kinds of metabolic disorders and the symptoms associated with those diseases. Herein, a novel, simple and sensitive sensor based on 3D peony-like bimetallic conductive MOFs (Co-Ni-MOFs) was fabricated for the electrochemical determination of Trp. The bimetallic conductive MOFs were synthesized by a facile one-pot hydrothermal process. On account of the synergy between the Ni2+ and Co2+ ions, the bimetallic Co-Ni-MOFs showed excellent electrochemical performance, including good conductivity, large effective surface areas, and high electrocatalytic reactivity toward the oxidation of Trp. Consequently, the Co-Ni-MOFs-modified electrodes obtained a wide linear range from 10 nmol L-1 to 300 mu mol L-1 and a low detection limit of 8.7 nmol L-1 (S/N = 3) for Trp. Additionally, the prepared sensor also displayed high selectivity, long-term stability and reproducibility. Moreover, the proposed sensor was successfully applied to determine the levels of Trp in the plasma of mice after cadmium intoxication.