SEX DIFFERENCE IN THE BED NUCLEUS OF THE STRIA TERMINALIS OF THE HUMAN BRAIN
SEX DIFFERENCE IN THE BED NUCLEUS OF THE STRIA TERMINALIS OF THE HUMAN BRAIN
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DOI：
10.1002/cne.903020402
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发表时间：
1990-12-22
影响因子：
2.5
通讯作者：
GORSKI, RA
中科院分区：
文献类型：
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作者：
ALLEN, LS;GORSKI, RA
对26例年龄匹配的男性和女性受试者的大脑终纹后内侧床核深染区域的体积进行了定量分析。我们建议使用终纹床核(BNST-dspm)的“深染后内侧”成分来描述人脑的这一性别二型性区域。男性BNST-dspm的体积是女性的2.47倍。人类的这一区域似乎对应于实验动物终纹床核的一个区域，该区域表现出体积和神经化学的性二态，集中性腺类固醇，并在解剖学上与其他几个性二态核相连。此外，终纹的床核涉及性二态功能，包括攻击行为、性行为和促性腺激素的分泌，这些功能也受到性腺类固醇的影响。因此，在人类中，性腺激素也可能影响BNST-dspm的性别二型性，这种形态差异在一定程度上是性二型性功能的基础。
A quantitative analysis of the volume of the darkly staining region of the posteromedial bed nucleus of the stria terminalis was performed on the brains of 26 age-matched male and female human subjects. We suggest the term "darkly staining posteromedial" component of the bed nucleus of the stria terminalis (BNST-dspm) to describe this sexually dimorphic region of the human brain. The volume of the BNST-dspm was 2.47 times greater in males than in females. This region in humans appears to correspond to an area of the bed nucleus of the stria terminalis in laboratory animals that exhibits volumetric and neurochemical sexual dimorphisms, concentrates gonadal steroids, and is anatomically connected to several other sexually dimorphic nuclei. Furthermore, the bed nucleus of the stria terminalis is involved in sexually dimorphic functions, including aggressive behavior, sexual behavior, and gonadotropin secretion, which are also influenced by gonadal steroids. Therefore, it is possible that in human beings as well, gonadal hormones influence the sexual dimorphism in the BNST-dspm and that this morphological difference, in part, underlies sexually dimorphic function.