Liver scanning in the assessment of liver damage from therapeutic external irradiation.
Liver scanning in the assessment of liver damage from therapeutic external irradiation.
复制标题
肝脏扫描评估治疗性外照射造成的肝损伤。
DOI：
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发表时间：
1966
期刊：
影响因子：
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通讯作者：
J. Usselman
中科院分区：
文献类型：
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作者：
J. Usselman
正常肝脏通常被认为是一个器官抵抗X射线照射时，在通常的治疗范围。然而，最近基于对接受放射治疗以控制睾丸肿瘤的患者的肝脏扫描研究的观察表明，肝脏实际上可能对X射线照射非常敏感。病例（1）回顾了早期文献，并引用了Seklin在1903-04年的实验工作，他发现辐照和未辐照的肝细胞之间没有组织学差异。Heinke（1904）证实了Seldin的工作。Werthin（1905）已证实接受辐照治疗的人的肝脏出现萎缩、慢性被动充血和轻微的实质变性，但其影响是非特异性的，且辐照的因果关系无法明确确立。Tribondeau和Hudelet（1907）在糖尿病患者中使用分次剂量无法证明明确的损害。Ellinger（2）指出，临床医生和研究人员对肝脏的放射敏感性或放射抗性没有达成一致意见。存在肝细胞损伤的阈值，其大约等于任何动物物种的LD 80，并且如果给予分次照射，则仅在给予绝对致死剂量后才会导致肝损伤。他还指出，肝细胞的死亡可能是由组胺的作用间接引起的，与肝脏损伤的总效应有关
The normal liver has generally been considered an organ resistent to x-ray irradiation when given in the usual therapeutic range. Recent observation based on study of liver scans of patients undergoing irradiation for control of testicular tumors suggest, however, that the liver may in fact be quite sensitive to x-irradiation. Case ( 1 ) reviewed the early literature and cited the experimental work of Seklin in 1903-04 who found no histologic differences between irradiated and nonirradiated liver cells. Heinke (1904) confirmed the work of Seldin. Werthin (1905) had demonstrated atrophy, chronic passive congestion and minimal parenchymal degeneration in the liver of humans who were treated by irradia tion, but the effects were nonspecific and the causal relationship of the irradia tion could not be established definitely. Tribondeau and Hudelet (1907) using fractionated doseage in diabetics were unable to demonstrate definite damage. Ellinger( 2) has stated no agreement exists among clinicians and investigators as to the radiosensitivity or radioresistence of the liver. A threshold for liver cell injury exists which approximately equals the LD8O for any species of animal and if fractionated irradiation is administered, liver damage will result only after an absolute lethal dose is given. He also pointed out that liver cell death may be caused indirectly by the action of histamine, and the total effect of liver damage