Seeing strangers or announcing "danger": Galectin-3 in two models of innate immunity
Seeing strangers or announcing "danger": Galectin-3 in two models of innate immunity
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DOI：
10.1023/b:glyc.0000014089.17121.cc
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发表时间：
2002-01-01
影响因子：
3
通讯作者：
Nieminen, J
中科院分区：
文献类型：
--
作者：
Sato, S;Nieminen, J
最近对我们的免疫系统识别感染并启动防御这些感染的分子机制的研究导致了两个模型的命题，解释了我们的先天免疫系统的功能方式；自我-非我模型和危险模型。本文就半乳糖凝集素-3在抗感染-宿主-病原体相互作用的先天免疫中的作用进行综述。我们将从自我-非自我模型和危险模型的角度阐明β -半乳糖苷结合哺乳动物凝集素-3作为一种与先天免疫有关的分子的潜在贡献。
Recent investigations on the molecular mechanisms by which our immune system recognizes infections and initiates defense against those infections have led to the proposition of two models explaining the way our innate immunity system functions; the self-nonself model and the Danger model. In this review, the roles of galectin-3 in innate immunity against infections-host-pathogen interactions-will be discussed. We will shed light on the potential contribution of a beta-galactoside binding mammalian lectin, galectin-3 as a molecule implicated in innate immunity from the angle of both the self-nonself model and the Danger model.