Microfluidics-Based Sensing of Biospecies
Microfluidics-Based Sensing of Biospecies
复制标题
基于微流体的生物物种传感
DOI：
10.1021/acsabm.0c01271
复制
发表时间：
2020
影响因子：
4.7
通讯作者：
Fabiao Yu
中科院分区：
文献类型：
--
作者：
Yanlong Xing;Linlu Zhao;Ziyi Cheng;Chuanzhu Lv;Feifei Yu;Fabiao Yu
在过去的几十年里，基于许多先进技术的微流控器件在化学、生物和分析应用领域引起了广泛的关注。微器件与各种芯片设计的集成将促进有前途的功能。值得注意的是，微流体与功能性纳米材料的结合可以提供创造性的想法，以实现对各种生物物种的快速和灵敏的检测。在这篇综述中，专注于微流体和微器件在其制造，集成和功能方面，我们总结了最新的发展，基于微流体的生物物种分析，其中生物标志物，小分子，细胞和病原体作为代表性的生物物种进行了深入的探讨。最后讨论了微流控生物传感器在临床诊断、食品安全控制、环境监测等方面的应用前景。这篇综述旨在强调基于微流体的生物传感器在实现高通量、高灵敏度和低成本分析方面的重要性，并促进微流体技术走向更广泛的应用。
Over the past decades, microfluidic devices based on many advanced techniques have aroused widespread attention in the fields of chemical, biological, and analytical applications. Integration of microdevices with a variety of chip designs will facilitate promising functionality. Notably, the combination of microfluidics with functional nanomaterials may provide creative ideas to achieve rapid and sensitive detection of various biospecies. In this review, focused on the microfluids and microdevices in terms of their fabrication, integration, and functions, we summarize the up-to-date developments in microfluidics-based analysis of biospecies, where biomarkers, small molecules, cells, and pathogens as representative biospecies have been explored in-depth. The promising applications of microfluidic biosensors including clinical diagnosis, food safety control, and environmental monitoring are also discussed. This review aims to highlight the importance of microfluidics-based biosensors in achieving high throughput, highly sensitive, and low-cost analysis and to promote microfluidics toward a wider range of applications.