An institutional pilot study to investigate physical activity patterns in boys with haemophilia
An institutional pilot study to investigate physical activity patterns in boys with haemophilia
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DOI：
10.1111/hae.13021
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发表时间：
2016-09-01
期刊：
影响因子：
3.9
通讯作者：
Carcao, M.
中科院分区：
文献类型：
--
作者：
Bouskill, V.;Hilliard, P.;Carcao, M.
简介：血友病是一种以肌肉骨骼出血为特征的出血性疾病。创伤引起的关节和肌肉出血可能与参与体育活动有关。认识到这一点，血友病患者可能会限制体力活动，以避免出血。不同严重程度血友病儿童的体力活动特征（类型、强度、频率和持续时间）尚未得到充分记录。这是需要更好地了解身体活动和血友病儿童出血之间的关系。目的：本研究是一项前瞻性、横断面、观察性研究，旨在比较不同血友病严重程度男孩通过加速度计测量的体力活动的数量、类型和强度。方法：受试者每天佩戴加速度计1周，并完成经验证的自我报告PedHAL和3DPAR问卷。加速度计活动水平分为久坐、轻度、中度或剧烈。结果：共有66名男性入组，24名患有轻度/中度血友病，42名患有重度血友病。受试者平均年龄为11.52岁（+/- 3.99），平均BMI为20.74 kg m2（+/- 5.68）。与轻度/中度血友病男孩相比，重度血友病男孩报告每天久坐活动的时间明显更多。此外，从事久坐不动的活动的时间量随着年龄的增长，在这些男孩与严重的血友病，而相反的是，在那些与轻度/中度血友病。结论：我们推测，重度血友病儿童的预防治疗使他们能够进行与轻度/中度血友病儿童相似的中度至剧烈体力活动（MVPA）。随着年龄的增长，严重队列中久坐时间的增加可能归因于其他心理社会因素中关节病的增加。
Introduction: Haemophilia is a bleeding disorder characterized by musculoskeletal bleeding. Trauma-induced bleeding into joints and muscles may be associated with participation in physical activities. Recognizing this, persons with haemophilia may limit physical activities to avoid bleeding. The characterization of physical activity profiles (type, intensity, frequency and duration) in children with differing severities of haemophilia has not been well documented. This is required to better understand the relationship between physical activity and bleeding in children with haemophilia. Aim: This study was a prospective, cross-sectional, observational study to compare the quantity, type and intensity of physical activity as measured by accelerometry in boys with different haemophilia severities. Methods: Subjects wore an accelerometer daily for 1 week and completed validated self-report PedHAL and 3DPAR questionnaires. Accelerometer activity levels were classified as sedentary, light, moderate or vigorous. Results: A total of 66 males were enrolled, 24 had mild/moderate and 42 had severe haemophilia. Subjects average age was 11.52 years (+/- 3.99) and their average BMI was 20.74 kg m(2) (+/- 5.68). Boys with severe haemophilia reported significantly more time per day spent in sedentary activities compared to those with mild/moderate haemophilia. Furthermore, the amount of time engaged in sedentary activities increased with age in those boys with severe haemophilia, whereas the opposite was true in those with mild/moderate haemophilia. Conclusion: We speculate that prophylaxis in children with severe haemophilia permitted them to engage in similar amounts of moderate to vigorous physical activity (MVPA) as children with mild/moderate haemophilia. Increasing sedentary time in the severe cohort with age may be attributed to increasing arthropathy among other psychosocial factors.