Response of lymphosarcoma LS/BL cells to continuous irradiation.
Response of lymphosarcoma LS/BL cells to continuous irradiation.
复制标题
淋巴肉瘤 LS/BL 细胞对连续照射的反应。
DOI：
10.2307/3576418
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发表时间：
1984
影响因子：
3.4
通讯作者：
V. Drášil
中科院分区：
文献类型：
--
作者：
V. Jurásková;V. Drášil
以每天1.2戈伊（5 rad/hr）的低照射率对C57 BL小鼠腹腔中作为腹水瘤生长的小鼠淋巴肉瘤LS/BL细胞进行体内连续照射。腹水肿瘤的生长通过直接计数腹膜腔中的细胞及其在肝脏中形成集落的能力来评估，随着连续照射时间的增加而下降。以宿主存活时间为终点，采用连续稀释法和肝集落形成实验研究了LS/BL细胞的辐射敏感性和修复能力。LS/BL-CI细胞经连续照射后，其放射敏感性无明显变化，但从照射第150周开始，存活曲线上出现起始肩，其宽度随照射时间延长而增加。照射350周后，外推数（n）从1.0增加到8.4。用分次剂量技术证实了初始肩的再现。
Mouse lymphosarcoma LS/BL cells growing as an ascites tumor in the peritoneal cavity of C57BL mice were continuously irradiated in vivo at a low exposure rate of 1.2 Gy per day (5 rad/hr). The growth of the ascites tumor evaluated by direct counting of the cells in the peritoneal cavity and their capacity to form colonies in livers declined with increasing time of continuous irradiation. The radiosensitivity and repair ability of LS/BL cells were studied by a serial dilution method using host survival time as the end point and by the liver colony assay. The radiosensitivity of continuously irradiated LS/BL-CI cells showed no remarkable change as measured by the Do values, but from the 150th week of irradiation the initial shoulder on the survival curves appeared and its width increased with time of exposure. The extrapolation number (n) increased from 1.0 to 8.4 after 350 weeks of irradiation. The reappearance of the initial shoulder was proved with the split-dose technique.