A new norcembranoid dimer from the Red Sea soft coral Sinularia gardineri
A new norcembranoid dimer from the Red Sea soft coral Sinularia gardineri
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DOI：
10.1021/np960207z
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发表时间：
1996-07-01
影响因子：
5.1
通讯作者：
Hamann, MT
中科院分区：
文献类型：
--
作者：
ElSayed, KA;Hamann, MT
对采自红海的中华乳杆菌(Sinularia gardineri(Pratt)(Alcyoniidae))进行了研究，发现了一种新的七环降膜二聚体Singardin(1)。通过光谱分析，确定了其结构。分离得到了已知的倍半萜-愈创木二醇(2)、已知的西莫内酯(1R，5S，8R)、10S，11R)-11-hydroxy-1-isoprenyl-8-methyl-3，6-dioxo-5，8-epoxycyclotetradec-12-ene 10，12-内酯(5-表-芥子内酯)和芥子内酯。化合物1和2对小鼠白血病(P-388)、人肺癌(A-549)、人结肠癌(HT-29)和人黑色素瘤细胞(MEL-28)具有细胞毒性。
A study of Sinularia gardineri (Pratt) (Alcyoniidae), collected in the Red Sea, revealed a new heptacyclic norcembranoid dimer singardin (1). The structure of singardin was deduced by spectroscopic analysis. A known sesquiterpene, guaianediol (2), and the known cembranolides (1R,5S,8R, 10S,11R)-11-hydroxy-1-isoprenyl-8-methyl-3,6-dioxo-5,8-epoxycyclotetradec-12-ene 10,12-carbolactone (5-epi-sinuleptolide) and sinuleptolide were also isolated. Compounds 1 and 2 show cytotoxicity to murine leukemia (P-388), human lung carcinoma (A-549), human colon carcinoma (HT-29), and human melanoma cells (MEL-28).