DECREASED PROTEIN-BINDING OF SALICYLATES IN KAWASAKI-DISEASE
DECREASED PROTEIN-BINDING OF SALICYLATES IN KAWASAKI-DISEASE
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DOI：
10.1016/s0022-3476(05)82168-7
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发表时间：
1991-03-01
影响因子：
5.1
通讯作者：
BURNS, JC
中科院分区：
文献类型：
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作者：
KOREN, G;SILVERMAN, E;BURNS, JC
由于川崎病患者血清中水杨酸盐浓度低，尽管剂量大，而且游离（未结合）药物是水杨酸盐的药理作用的原因，我们评估了川崎病患者体内水杨酸盐蛋白结合情况。在疾病急性期，36例川崎病患儿的水杨酸蛋白结合率为73 +/- 12%，显著低于亚急性期（90.4 +/- 8.7%,p < 0.0005）。急性期平均血清白蛋白浓度为29.2 +/- 6.4 gm/L，随后亚急性期平均血清白蛋白浓度为36.7 +/- 7.8 gm/L （p < 0.005）。水杨酸蛋白结合受血清白蛋白和总水杨酸水平的独立影响。在川崎病急性期，与正常白蛋白血症对照组相比，儿童游离水杨酸平均增加两倍。已经设计了一个nomogram从已知的总水杨酸和血清白蛋白浓度中得出游离水杨酸水平。
Because patients with Kawasaki disease have low serum concentrations of salicylates despite high doses, and because the free (unbound) drug is responsible for the pharmacologic effects of salicylates, we assessed salicylate protein binding in patients with Kawasaki disease. During the acute phase of the disease, protein binding of salicylate in 36 children with Kawasaki disease was 73 +/- 12%, significantly lower than during the subacute phase (90.4 +/- 8.7%; p < 0.0005). Mean serum albumin concentration was 29.2 +/- 6.4 gm/L during the acute phase and 36.7 +/- 7.8 gm/L during the subsequent subacute phase (p < 0.005). Salicylate protein binding was affected independently by both serum albumin and total salicylate levels. During the acute phase of Kawasaki disease, children had an average twofold increase in free salicylate compared with normoalbuminemic control subjects. A nomogram has been devised to derive free salicylate levels from the known total salicylate and serum albumin concentrations.