XID IMMUNODEFICIENCY IMPARTS INCREASED PARASITE CLEARANCE AND RESISTANCE TO PATHOLOGY IN EXPERIMENTAL CHAGAS-DISEASE
XID IMMUNODEFICIENCY IMPARTS INCREASED PARASITE CLEARANCE AND RESISTANCE TO PATHOLOGY IN EXPERIMENTAL CHAGAS-DISEASE
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DOI：
10.1093/intimm/3.5.427
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发表时间：
1991-05-01
影响因子：
4.4
通讯作者：
HONTEBEYRIEJOSKOWICZ, M
中科院分区：
文献类型：
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作者：
MINOPRIO, P;COUTINHO, A;HONTEBEYRIEJOSKOWICZ, M
克氏锥虫感染几种小鼠品系会刺激高水平的T和B淋巴细胞活性，这些活性在慢性期持续存在，随后出现特异性免疫抑制和严重的自身免疫病理学。 携带X连锁突变且缺乏CD 5 B细胞的感染BALB.Xid小鼠显示出对T.克氏感染，伴随着血清中特异性和非特异性免疫球蛋白水平低。 然而，这些动物控制寄生虫血症，不显示在BALB/c小鼠中观察到的消瘦，并且在慢性期早期几乎没有发生病理学。 （BALB.Xid雌性x BALB/c雄性）F1动物的感染表明，免疫缺陷雄性的行为与Xid动物相似，而雌性的反应与正常BALB/c小鼠相似。 这些结果表明，Xid基因座控制淋巴细胞反应，寄生虫清除和实验性恰加斯病的病理。
Infection of several mouse strains with Trypanosoma cruzi stimulates high levels of T and B lymphocyte activities which persist during the chronic phase and is followed by specific immunosuppression and severe autoimmune pathology. Infected BALB.Xid mice carrying an X-linked mutation and lacking CD5 B cells, display poor B cell responses to T. cruzi infection, accompanied by low levels of specific and non-specific immunoglobulins in the serum. However, these animals control parasitemia, do not show the wasting observed in BALB/c mice, and develop almost no pathology early in the chronic phase. The infection of (BALB.Xid female x BALB/c male) F1 animals shows that immunodefective males behave like Xid animals in contrast to females which respond as normal BALB/c mice. These results indicate that the Xid locus controls lymphocyte responses, parasite clearance and pathology in experimental Chagas' disease.