The European Community Respiratory Health Survey II
The European Community Respiratory Health Survey II
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DOI：
10.1183/09031936.02.00046802
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发表时间：
2002-11-01
影响因子：
24.3
通讯作者：
Jarvis, D
中科院分区：
文献类型：
--
作者：
Jarvis, D
欧洲共同体呼吸健康调查（ECRHS）II将确定生活在欧洲的中年人中过敏性疾病、特应性和肺功能迅速丧失的发病率和危险因素，从1991-1993年，超过18，000人参加了ECRHS I，并提供了有关哮喘症状和暴露于已知或疑似危险因素的信息。采集血液样本用于评估对环境变应原的特异性免疫球蛋白E，并评估肺功能和支气管对乙酰甲胆碱的反应性。从1999年至2001年，研究参与者再次接触，以确定症状状态和暴露于各种因素，包括烟草烟雾，动物，职业代理和空气污染物（包括颗粒物）。在应答者的子样本中，通过分析从参与者床垫中采集的灰尘样本来评估屋尘螨过敏原的暴露。此外，还收集和储存了适合提取脱氧核糖核酸的血液样本，目前正在14个国家的29个中心进行欧洲共同体呼吸健康调查II。在撰写本文时，27个中心已经开始了这项研究，大约12,000名参与者完成了一份简短的邮寄问卷，大约9,000名参与者完成了更详细的健康评估，3,500名参与者提供了灰尘样本。对历史空气污染数据进行了整理，并在10个国家的21个中心完成了对空气动力学直径为2.5微米的颗粒物进行50%截止值监测的方案。
The European Community Respiratory Health Survey (ECRHS) II will determine the incidence of and risk factors for the development of allergic disease, atopy and rapid loss of lung function in middle-aged adults living in Europe.From 1991-1993, >18,000 individuals took part in ECRHS I and provided information on symptoms and exposure to known or suspected risk factors for asthma. Blood samples for assessment of specific immunoglobulin E to environmental allergen were taken and lung function and bronchial responsiveness to methacholine were assessed. From 1999-2001, study participants were re-contacted to determine symptom status and exposure to a variety of factors, including tobacco smoke, animals, occupational agents and air pollutants (including particulate matter). In a subsample of responders, exposure to house dust-mite allergen was assessed by analysis of dust samples taken from participants' mattresses. In addition, blood samples suitable for deoxyribonucleic acid extraction were collected and stored.Currently, European Community Respiratory Health Survey II is being conducted in 29 centres in 14 countries. At the time of writing this paper, 27 centres had begun the study and similar to12,000 participants had completed a short postal questionnaire, similar to9,000 had completed a more detailed health assessment and 3,500 participants had provided dust samples. Historical air-pollution data have been collated and the programme of monitoring particles with a 50% cut-off aerodynamic diameter of 2.5 mum has been completed in 21 centres in 10 countries.