Predictors of blood volatile organic compound levels in Gulf coast residents.
Predictors of blood volatile organic compound levels in Gulf coast residents.
复制标题
墨西哥湾沿岸居民血液挥发性有机化合物水平的预测因子。
DOI：
10.1038/s41370-017-0010-0
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发表时间：
2018
影响因子：
4.5
通讯作者：
Sandler,DaleP
中科院分区：
文献类型：
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作者：
Werder,EmilyJ;Gam,KaitlynB;Engel,LawrenceS;Kwok,RichardK;Ekenga,ChristineC;Curry,MatthewD;Chambers,DavidM;Blair,Aaron;Miller,AubreyK;Birnbaum,LindaS;Sandler,DaleP
为了解决墨西哥湾沿岸居民对持续暴露于挥发性有机化合物（包括苯、甲苯、二甲苯、邻二甲苯和间二甲苯/对二甲苯（BTEX））的担忧，我们描述了墨西哥湾沿岸居民目前的血液水平，并确定了BTEX的预测因子。我们收集了关于最近暴露的问卷数据，并在718名海湾居民的便利样本中测量了血液BTEX水平。由于BTEX从体内迅速清除，血液水平代表了过去24小时内的近期暴露。我们将参与者的血液BTEX水平与全国代表性样本进行了比较。在非吸烟者中，我们使用线性回归评估血液BTEX水平的预测因子，并使用改良泊松回归预测BTEX水平升高的风险。海湾居民的血液BTEX水平与全国水平相似。在非吸烟者中，性别和报告最近的烟雾/化学气味预测血液BTEX。女性和报告有异味的人的苯对数变化分别为-0.26（95% CI：-0.47，-0.04）和0.72（0.02，1.42）。季节，离家时间，和自我报告的住宅接近超级基金网站（半英里内）统计与苯只，但平均浓度几乎是一个数量级低于吸烟者。在这些海湾居民中，吸烟是血液BTEX水平的主要贡献者，但其他因素也相关。
To address concerns among Gulf Coast residents about ongoing exposures to volatile organic compounds, including benzene, toluene, ethylbenzene,o-xylene, andm-xylene/p-xylene (BTEX), we characterized current blood levels and identified predictors of BTEX among Gulf state residents. We collected questionnaire data on recent exposures and measured blood BTEX levels in a convenience sample of 718 Gulf residents. Because BTEX is rapidly cleared from the body, blood levels represent recent exposures in the past 24 h. We compared participants’ levels of blood BTEX to a nationally representative sample. Among nonsmokers we assessed predictors of blood BTEX levels using linear regression, and predicted the risk of elevated BTEX levels using modified Poisson regression. Blood BTEX levels in Gulf residents were similar to national levels. Among nonsmokers, sex and reporting recent smoky/chemical odors predicted blood BTEX. The change in log benzene was −0.26 (95% CI: −0.47, −0.04) and 0.72 (0.02, 1.42) for women and those who reported odors, respectively. Season, time spent away from home, and self-reported residential proximity to Superfund sites (within a half mile) were statistically associated with benzene only, however mean concentration was nearly an order of magnitude below that of cigarette smokers. Among these Gulf residents, smoking was the primary contributor to blood BTEX levels, but other factors were also relevant.