Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination
Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination
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DOI：
10.3389/fneur.2019.00600
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发表时间：
2019-06-07
影响因子：
3.4
通讯作者：
Taniwaki, Takayuki
中科院分区：
文献类型：
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作者：
Harada, Masaya;Miura, Shiroh;Taniwaki, Takayuki
我们描述了一位60岁的女性，患有中枢和外周脱髓鞘合并，她表现为顽固的便秘，下肢无力，胸部以下双侧感觉障碍，随后腹部右侧有束带感，对类固醇治疗和血浆置换有反应。血清抗乳糖神经酰胺抗体阳性，无抗神经束蛋白155抗体和抗半乳糖脑苷抗体阳性。两个月后，患者第一次复发，对类固醇治疗有反应。一项神经传导研究证实两例发作均有可逆性传导衰竭（RCF）。本病例的独特之处在于她有RCF发作，并且与脑脊髓根神经病变有一些相似之处。
We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy.