Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010
Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010
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Aspterpenacids A 和 B，两种来自红树林内生真菌 Aspergillus terreus H010 的二倍半萜类化合物
DOI：
10.1021/acs.orglett.6b00336
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发表时间：
2016-03-18
期刊：
影响因子：
5.2
通讯作者：
She, Zhigang
中科院分区：
文献类型：
--
作者：
Liu, Zhaoming;Chen, Yan;She, Zhigang
从红树林内生真菌Aspergillus terreus H 010中分离得到两个新的二倍半萜类化合物，Asperpenicacid A（1）和B（2），具有5/3/7/6/5环的碳骨架。它们的结构被阐明的基础上，光谱方法，单晶X-射线衍射分析，和电子圆二色性计算。提出了1和2的生物发生途径。1和2在50 μ M下均未显示出显着的抗菌活性或细胞毒性。
Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant antibacterial activity or cytotoxicity at 50 mu M.