Identifying early glaucoma with optical coherence tomography
Identifying early glaucoma with optical coherence tomography
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DOI：
10.1016/j.ajo.2003.09.004
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发表时间：
2004-02-01
影响因子：
4.2
通讯作者：
Caprioli, J
中科院分区：
文献类型：
--
作者：
Nouri-Mahdavi, K;Hoffman, D;Caprioli, J
目的：评价光学相干断层扫描（OCT）对早期青光眼的检测效果。设计：观察性病例对照研究。方法：（设置）酒吧：以大学为基础的三级医疗中心。（研究人群）条形图下：50例正常人，42例青光眼疑似患者，59例早期青光眼患者的单眼，符合以下标准：视野（VF）平均偏差大于等于6.00 dB，年龄大于等于40岁，球面屈光不小于等于5屈光度，散光小于等于3屈光度，视力大于等于20/ 30。（观察程序）栏下：早期青光眼由VF （EGVF）被描述为可重复的异常消色差VF，基于预定义的标准。青光眼疑似（GS）定义为存在青光眼盘状外观，VFs正常消色差。（结果测量）柱下：平均神经纤维层厚度（NFLT）和NFLT在每个四个象限和12个时钟小时扇区。结果：正常眼、GS眼和EGVF眼的平均NFLT分别为128.4 +/- 15.4、102.0 +/- 25.4和86.5 +/- 31.5 μ m。正常眼与两组青光眼差异有统计学意义(P
PURPOSE: To evaluate performance of optical coherence tomography (OCT) for detection of early glaucoma.DESIGN: Observational case-control study.METHODS: (Setting) under bar: University-based tertiary care center. (Study Population) under bar: One eye from 50 normals, 42 glaucoma suspects, and 59 early glaucoma patients meeting the following criteria: visual field (VF) mean deviation greater than or equal to-6.00 dB, age greater than or equal to40 years, spherical refractive error less than or equal to5 diopters, astigmatism less than or equal to3 diopters, and visual acuity greater than or equal to20/ 30. (Observation Procedure) under bar: Early glaucoma by VF (EGVF) was described as repeatable abnormal achromatic VFs based on predefined criteria. Glaucoma suspects (GS) were defined as presence of glaucomatous disk appearance with normal achromatic VFs. (Outcome Measures) under bar: Average nerve fiber layer thickness (NFLT) and NFLT in each of four quadrants and 12 clock-hour sectors. Receiver operating characteristic curves and sensitivity and specificity were used to assess the performance of OCT.RESULTS: Average NFLT was 128.4 +/- 15.4, 102.0 +/- 25.4, and 86.5 +/- 31.5 mum in normal, GS, and EGVF eyes, respectively. Normal eyes were different from both glaucoma groups (P