The Challenge of Reproducibility and Accuracy in Nutrition Research: Resources and Pitfalls.

The Challenge of Reproducibility and Accuracy in Nutrition Research: Resources and Pitfalls.
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营养研究再现性和准确性的挑战:资源和陷阱。

DOI:
10.3945/an.115.010595
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发表时间:
2016
影响因子:
9.3
通讯作者:
Joseph M Betz
Joseph M Betz
中科院分区:
医学2区
文献类型:
--
作者:
B. Sorkin;A. Kuszak;John S Williamson;D Craig Hopp;Joseph M Betz

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由不同研究者进行的营养研究的不一致和相互矛盾的结果继续出现,部分原因是天然产品的固有变异性,以及研究人群和实验设计中的未知和不可控变量。鉴于营养研究中固有的这些挑战,研究人员通过优化所使用的产品、试剂和模型系统的表征、控制和报告,以及严格性,努力最大限度地减少研究内的变异性并增强研究之间的可比性,对于该领域的进展至关重要。实验设计、方案和数据分析的报告。在这里,我们描述了与营养研究中使用的植物源性产品研究相关的一些最新进展,强调了一些用于优化使用这些产品的研究的表征和报告的资源,并描述了一些通过遵守这些建议可以避免的陷阱。
Inconsistent and contradictory results from nutrition studies conducted by different investigators continue to emerge, in part because of the inherent variability of natural products, as well as the unknown and therefore uncontrolled variables in study populations and experimental designs. Given these challenges inherent in nutrition research, it is critical for the progress of the field that researchers strive to minimize variability within studies and enhance comparability between studies by optimizing the characterization, control, and reporting of products, reagents, and model systems used, as well as the rigor and reporting of experimental designs, protocols, and data analysis. Here we describe some recent developments relevant to research on plant-derived products used in nutrition research, highlight some resources for optimizing the characterization and reporting of research using these products, and describe some of the pitfalls that may be avoided by adherence to these recommendations.
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