Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes.
Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes.
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低发病率国家艾滋病毒阴性和艾滋病毒感染者的结核病：临床特征和治疗结果。
DOI：
10.1371/journal.pone.0034186
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups
中科院分区：
文献类型：
--
作者：
Fenner L;Gagneux S;Janssens JP;Fehr J;Cavassini M;Hoffmann M;Bernasconi E;Schrenzel J;Bodmer T;Böttger EC;Helbling P;Egger M;Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups
在瑞士和其他发达国家，结核病(TB)病例的数量几十年来一直在下降，但艾滋病毒感染患者和移民仍然是危险群体。这项研究的目的是比较在瑞士确诊的艾滋病毒阴性和艾滋病毒感染患者的结核病特征，以及在瑞士国家艾滋病毒队列研究(SHCS)中登记和未登记的混合感染患者之间的结核病特征。纳入了2000-2008年在SHCS中被诊断为培养确认结核病的所有患者，以及向国家结核病登记中心报告的培养确认病例的随机样本。对艾滋病毒感染患者的结果进行评估，如果治愈或治疗完成，则认为是成功的。对随机抽取的93例SHCS患者和288例SHCS患者进行分析。登记样本包括10名(3.5%)未在SHCS登记的合并感染患者：2000-2008年，未登记在SHCS但向登记中心报告的艾滋病毒感染患者估计数量为146人(95%可信区间122-173)。与艾滋病毒阴性患者相比，混合感染患者更有可能来自撒哈拉以南非洲地区(51.5%比15.8%，P<；0.0001)，并且更有可能出现播散性疾病(23.9%比3.4%，P<；0.0001)。没有登记在深水卫生保健中心的混合感染者是寻求庇护者或外来务工人员，在诊断结核病时CD_4细胞计数较低(CD_4细胞数中位数79个/µL，而深水卫生中心患者为149个细胞/µL，P = 为0.07)。有6名患者(60.0%)获得成功，而SHC组82名患者(88.2%)获得成功(P = 0.023)。合并感染的肺结核患者与HIV阴性患者的临床表现不同。在SHCS之外被诊断为结核病的艾滋病毒感染患者的数量与队列中被诊断的数量相似，但在国家队列中没有得到随访的患者的结果更差。需要作出特别努力来满足这一弱势群体的需要。
In Switzerland and other developed countries, the number of tuberculosis (TB) cases has been decreasing for decades, but HIV-infected patients and migrants remain risk groups. The aim of this study was to compare characteristics of TB in HIV-negative and HIV-infected patients diagnosed in Switzerland, and between coinfected patients enrolled and not enrolled in the national Swiss HIV Cohort Study (SHCS). All patients diagnosed with culture-confirmed TB in the SHCS and a random sample of culture-confirmed cases reported to the national TB registry 2000–2008 were included. Outcomes were assessed in HIV-infected patients and considered successful in case of cure or treatment completion. Ninety-three SHCS patients and 288 patients selected randomly from 4221 registered patients were analyzed. The registry sample included 10 (3.5%) coinfected patients not enrolled in the SHCS: the estimated number of HIV-infected patients not enrolled in the SHCS but reported to the registry 2000–2008 was 146 (95% CI 122–173). Coinfected patients were more likely to be from sub-Saharan Africa (51.5% versus 15.8%, P<0.0001) and to present disseminated disease (23.9% vs. 3.4%, P<0.0001) than HIV-negative patients. Coinfected patients not enrolled in the SHCS were asylum seekers or migrant workers, with lower CD4 cell counts at TB diagnosis (median CD4 count 79 cells/µL compared to 149 cells/µL among SHCS patients, P = 0.07). There were 6 patients (60.0%) with successful outcomes compared to 82 (88.2%) patients in the SHCS (P = 0.023). The clinical presentation of coinfected patients differed from HIV-negative TB patients. The number of HIV-infected patients diagnosed with TB outside the SHCS is similar to the number diagnosed within the cohort but outcomes are poorer in patients not followed up in the national cohort. Special efforts are required to address the needs of this vulnerable population.
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影响因子：
3.7
作者：
Kherad, Omar;Herrmann, Francois R.;Janssens, Jean-Paul
通讯作者：
Janssens, Jean-Paul
影响因子：
11.8
作者：
Elzi, Luigia;Schlegel, Matthias;Furrer, Hansjakob
通讯作者：
Furrer, Hansjakob
影响因子：
1.9
作者：
Wolff, H.;Janssens, J. P.;Morabia, A.
通讯作者：
Morabia, A.
DOI：
10.1086/595705
发表时间：
2009-01-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Mugavero MJ;Lin HY;Willig JH;Westfall AO;Ulett KB;Routman JS;Abroms S;Raper JL;Saag MS;Allison JJ
通讯作者：
Allison JJ
影响因子：
168.9
作者：
Braitstein, P;Brinkhof, MWG;Egger, M
通讯作者：
Egger, M