Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy
Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy
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DOI：
10.1038/nm.1902
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发表时间：
2009-01-01
期刊：
影响因子：
82.9
通讯作者：
Filipowicz, Witold
中科院分区：
文献类型：
--
作者：
Sarasin-Filipowicz, Magdalena;Krol, Jacek;Filipowicz, Witold
包括肝脏特异性miR-122在内的几种microRNA（miRNAs）参与了人类肝癌细胞中丙型肝炎病毒（HCV）RNA复制及其对干扰素（IFN）的反应。我们对接受IFN治疗的慢性丙型肝炎（CHC）受试者的肝活检进行的分析显示，miR-122表达与病毒载量无关，并且在后来的IFN治疗期间没有病毒学反应的受试者中，治疗前miR-122水平显着降低;其他研究的miRNA仅显示有限的变化。这些数据对靶向miRNA用于CHC治疗的前景具有启示作用。
Several microRNAs (miRNAs), including liver-specific miR-122, have been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Our analysis of liver biopsies from subjects with chronic hepatitis C (CHC) undergoing IFN therapy revealed no correlation of miR-122 expression with viral load and markedly decreased pretreatment miR-122 levels in subjects who had no virological response during later IFN therapy; other investigated miRNAs showed only limited changes. These data have implications for the prospect of targeting miRNAs for CHC therapy.