One airway, one disease
One airway, one disease
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DOI：
10.1378/chest.111.2_supplement.11s
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发表时间：
1997-02-01
期刊：
影响因子：
9.6
通讯作者：
Grossman, J
中科院分区：
文献类型：
--
作者：
Grossman, J
哮喘和过敏性鼻炎的患病率在普通人群中不断增加，并且高比例的新患者同时患有上呼吸道和下呼吸道疾病，估计显示60 - 78%的哮喘患者同时患有过敏性鼻炎，在过去的十年中，我们对哮喘和过敏性鼻炎的理解已经发展，这些过敏原诱导的疾病作为不同和独立实体的历史观点被当前的思想所取代，当前的思想认为它们被更好地描述为涉及一个共同气道的连续炎症，因此，最初用于过敏性鼻炎和哮喘的传统疗法正在被重新评估，以探索它们在上呼吸道和下呼吸道疾病中的潜在效用。最近，人们重新关注组胺在下呼吸道疾病中的作用，并且对白三烯，其是比组胺更有效的炎症介质，在上呼吸道疾病中起作用。鉴于白三烯在双气道炎症的病理生理状态中作为有效的炎症介质发挥的关键作用，白三烯受体拮抗剂最近已成为重要的治疗进展，在哮喘和过敏性鼻炎中具有潜在的临床应用。
The prevalence of asthma and allergic rhinitis is increasing in the general population, and a high proportion of new patients have coexisting upper and lower airway disease, Estimates show that 60 to 78% of patients who have asthma have coexisting allergic rhinitis, During the past decade, our understanding of asthma and allergic rhinitis has evolved, The historic perspective of these allergen-induced disorders as distinct and separate entities is being displaced by current thinking that they are described better as a continuum of inflammation involving one common airway, Therefore, traditional therapies originally indicated for allergic rhinitis and asthma are being reassessed to explore their potential utility in both upper and lower airway diseases, Recently, there has been a renewed interest in the role that histamines play in lower airway disease, and interest is increasing in the theory that leukotrienes, which are far more potent inflammatory mediators than histamines, play a role in upper airway disease. Given the pivotal role that leukotrienes play as potent inflammatory mediators in the pathophysiologic state of inflammation of both airways, leukotriene receptor antagonists recently have emerged as important therapeutic advances that have potential clinical utility in both asthma and allergic rhinitis.