Socio-demographic factors, reproductive history and risk of osteoarthritis in a cohort of 4.6 million Danish women and men
Socio-demographic factors, reproductive history and risk of osteoarthritis in a cohort of 4.6 million Danish women and men
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DOI：
10.1016/j.joca.2011.07.009
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发表时间：
2011-10-01
影响因子：
7
通讯作者：
Frisch, M.
中科院分区：
文献类型：
--
作者：
Jorgensen, K. T.;Pedersen, B. V.;Frisch, M.
目的：关于骨关节炎（OA）病因学中可能的社会人口学和生殖因素的研究很少。我们研究了可能的影响，教育水平，家庭收入，婚姻状况和养育模式对OA风险的整体和解剖sites.Method：我们联系了国家登记册的数据，社会人口变量，生育史和OA医院接触到一个队列的460万丹麦人。首次OA住院率（RR）的比率计算使用Poisson regression.Results：总体而言，100，437名女性和92，020名男性在1982年至2008年的9150万人年期间首次OA医院接触。短期教育、低收入和婚姻状况与OA风险增加显著相关，有孩子的人患OA的风险更高（总体）（女性RR = 1.10;男性RR = 1.22），OA（膝关节）（RR 1.14; 1.28）、OA（背部）（RR 1.18; 1.33）和OA（手部）（RR 1.21; 1.43），但OA（髋部）（RR 0.96; 1.00）与无子女的人相比无差异。OA的RR（整体）增加了1.05倍的妇女和1.04在男性每增加一个孩子，最明显的OA（膝关节）在妇女（1.10每儿童）。结论：OA住院的风险是最高的已婚人士和短期教育或低收入的人。男性生殖因素与女性相似或甚至更强的相关性表明，未测量的生活方式因素而不是与怀孕相关的生物因素可能解释了有孩子的人的OA风险较高。然而，产次与女性OA（膝关节）风险之间的特别强的相关性与妊娠相关因素的作用是一致的。(C)2011年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: Studies addressing possible socio-demographic and reproductive factors in the aetiology of osteoarthritis (OA) are few. We studied possible influences of educational level, household income, marital status and parenting patterns on OA risk overall and at anatomical sites.Method: We linked national register data about socio-demographic variables, reproductive histories and OA hospital contacts to a cohort of 4.6 million Danes. Ratios of first OA hospitalisation rates (RRs) were calculated using Poisson regression.Results: Overall, 100,437 women and 92,020 men had a first OA hospital contact during 91.5 million person-years between 1982 and 2008. Short education, low income and married status were significantly associated with increased OA risk, and persons with children were at higher risk of OA(overall) (RR = 1.10 in women; RR = 1.22 in men), OA(knee) (RRs 1.14:1.28), OA(back) (RRs 1.18; 1.33), and OA(hand) (RRs 1.21; 1.43), but not of OA(hip) (RRs 0.96; 1.00) than persons without children. The RR of OA(overall) increased by a factor of 1.05 in women and 1.04 in men per additional child, most notably for OA(knee) in women (1.10 per child).Conclusion: Risk of OA hospitalisation was highest among married persons and persons with short education or low income. The similar or even stronger associations with reproductive factors in men than women suggest that unmeasured lifestyle factors rather than biological factors associated with pregnancy might explain the higher OA risk in persons with children. However, the particularly strong association between parity and risk of OA(knee) in women is compatible with a role of pregnancy-associated factors. (C) 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.