Common variants of xeroderma pigmentosum genes and prostate cancer risk
Common variants of xeroderma pigmentosum genes and prostate cancer risk
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DOI：
10.1016/j.gene.2014.06.026
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发表时间：
2014-08-10
期刊：
影响因子：
3.5
通讯作者：
Debniak, Tadeusz
中科院分区：
文献类型：
--
作者：
Mirecka, Aneta;Paszkowska-Szczur, Katarzyna;Debniak, Tadeusz
前列腺癌（PC）的遗传基础是复杂的，似乎涉及多个易感基因。许多研究已经评估了几种NER基因多态性与PC风险之间的可能相关性，但大多数研究仅评估了XP基因中的单个SNP，结果仍然不一致。在位于7个XP基因（XPA-XPG）的94个SNPs中，共检测了720名PC患者的15个SNPs，并与1121名健康成人进行了比较。与对照人群相比，XPD SNP rs 1799793（Asp 312 Asn）AG基因型（OR = 2.60; p < 0.001）和AA基因型（OR = 531; p < 0.0001）与疾病风险增加相关。XPD的单倍型分析揭示了一种保护性单倍型和四种与疾病风险增加相关的单倍型，这表明A等位基因（XPD rs 1799793）似乎驱动了促进前列腺癌风险的主要作用。XPD基因多态性可能与前列腺癌的发病风险有关。(C)2014由Elsevier B. V.出版
The genetic basis of prostate cancer (PC) is complex and appears to involve multiple susceptibility genes. A number of studies have evaluated a possible correlation between several NER gene polymorphisms and PC risk, but most of them evaluated only single SNPs among XP genes and the results remain inconsistent. Out of 94 SNPs located in seven XP genes (XPA-XPG) a total of 15 SNPs were assayed in 720 unselected patients with PC and compared to 1121 healthy adults. An increased risk of disease was associated with the XPD SNP, rs1799793 (Asp312Asn) AG genotype (OR = 2.60; p < 0.001) and with the AA genotype (OR = 531; p < 0.0001) compared to the control population. Haplotype analysis of XPD revealed one protective haplotype and four associated with an increased disease risk, which showed that the A allele (XPD rs1799793) appeared to drive the main effect on promoting prostate cancer risk. Polymorphism in XPD gene appears to be associated with the risk of prostate cancer. (C) 2014 Published by Elsevier B.V.