Reassessment of the impact of mucosal immunity in infection with the human immunodeficiency virus (HIV) and design of relevant vaccines.
Reassessment of the impact of mucosal immunity in infection with the human immunodeficiency virus (HIV) and design of relevant vaccines.
复制标题
重新评估粘膜免疫对人类免疫缺陷病毒（HIV）感染的影响并设计相关疫苗。
DOI：
10.1007/bf01540979
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发表时间：
1994
影响因子：
9.1
通讯作者：
Jackson,S
中科院分区：
文献类型：
--
作者：
Mestecky,J;Jackson,S
结论：开发能够在生殖道分泌物中诱导特异性免疫应答的疫苗，不仅对预防艾滋病和性传播疾病，而且对生育力的免疫控制具有深远的意义（4，76，88，89，123，124，149）。目前研究的大多数疫苗利用全身免疫途径，这对于预防粘膜感染疾病的价值有限。来自PP或其他诱导位点（例如，直肠扁桃体）到远处或邻近的效应部位（例如，生殖道），尽管其具有不容置疑的实际重要性，但尚未在人类中进行广泛研究。探索有效诱导粘膜免疫应答的免疫途径，这些途径主要基于目前对抗体来源和粘膜组织中特异性抗体形成细胞的认识，以及新的抗原递送系统（1，76，89，130），有可能降低许多传染病，包括艾滋病的发病率，也降低了这种疫苗的管理成本。
ConclusionsThe development of vaccines that would induce specific immune responses in the genital tract secretions would have far-reaching implications for not only the prevention of AIDS and sexually transmitted diseases but also the immunological control of fertility (4, 76, 88, 89, 123, 124, 149). Most of the currently studied vaccines utilize systemic routes of immunization which are of limited value for the prevention of mucosa-contracted diseases. The relative contribution of antigensensitized cells from PP or other inductive sites (e.g., rectal tonsils) to remote or adjacent effector sites (e.g., genital tract) as manifested by the appearance of corresponding S-IgA antibodies has not been studied extensively in humans despite its unquestionable practical importance. Exploration of immunization routes that are effective for induction of mucosal immune responses and that are based primarily on current knowledge of the origin of antibodies and of specific antibody-forming cells in mucosal tissues, together with novel antigen delivery systems (1, 76, 89, 130), is likely to reduce the incidence of many infectious diseases including AIDS and also reduce the cost of administration of such vaccines.