Novel potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G: derivatives of isothiazolidin-3-one.
Novel potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G: derivatives of isothiazolidin-3-one.
复制标题
人类白细胞弹性蛋白酶和组织蛋白酶 G 的新型潜在机制抑制剂：异噻唑烷-3-酮衍生物。
DOI：
10.1006/bbrc.1993.2540
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发表时间：
1993
影响因子：
3.1
通讯作者：
Venkataraman,R
中科院分区：
文献类型：
--
作者：
Groutas,WC;Chong,LS;Venkataraman,R
合成了一系列杂环化合物，并对其抑制活性进行了研究。发现这些异噻唑烷-3-酮衍生物是组织蛋白酶G的有效抑制剂。
A series of heterocydic compounds designed to function as mechanism-based inhibitors of human leukocyte elastase and cathepsin G has been synthesized and their inhibitory activity was investigated. These isothiazolidin-3-one derivatives were found to be effective inhibitors of cathepsin G.