Epithelial changes in gingivitis
Epithelial changes in gingivitis
复制标题
牙龈炎的上皮变化
DOI：
10.1111/j.1600-0765.1968.tb01936.x
复制
发表时间：
1968
影响因子：
3.5
通讯作者：
H. Thilander
中科院分区：
文献类型：
--
作者：
H. Thilander
电镜观察炎症引起的上皮结构变化。该材料包括12名成年患者的牙龈炎活检。在上皮中观察到的第一个变化是细胞间隙变宽。中度增宽时仍可见中间连接、紧密连接和桥粒。随着加宽的增加，中间连接首先消失，然后是紧密连接，作为随后的变化，桥粒的数量减少。上皮细胞间常可见不同类型的白细胞。在某些区域，致密层弥漫或完全缺失。这是真实的故障还是人为的故障很难确定。上皮细胞胞质内糖原颗粒增多，线粒体肿胀，嵴减少。
更高级的变化包括细胞质的局部解体和细胞死亡前的其他类型的变化。这些形态学变化后上皮通透性的可能影响进行了讨论。
The changes in epithelial structure due to inflammation were studied with the electron microscope. The material comprised biopsies from inflamed gingivae in 12 adult patients. The first change noticed in the epithelium was a widening of the intercellular spaces. When the widening was of moderate degree intermediate junctions, tight junctions and desmosomes were still observed. With increased widening the intermediate junctions disappeared first, then the tight junctions and, as a subsequent change there was a reduction in the number of the desmosomes. Leucocytes of different types were often present between the epithelial cells. In some areas, the lamina densa was diffuse or completely absent. Whether this was a real breakdown or an artefact is difficult to decide. In the cytoplasm of the epithelial cells there were numerous glycogen granules and swollen mitochondria with reduced numbers of cristae.
More advanced changes consisted of localised disintegration of cytoplasm and other changes of the type that precede cell death. The possible effects of these morphological changes upon epithelial permeability are discussed.