Diabetes and Poor Outcomes Within 6 Months After Acute Ischemic Stroke The China National Stroke Registry
Diabetes and Poor Outcomes Within 6 Months After Acute Ischemic Stroke The China National Stroke Registry
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DOI：
10.1161/strokeaha.111.621649
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发表时间：
2011-10-01
期刊：
影响因子：
8.3
通讯作者：
Wang, Yongjun
中科院分区：
文献类型：
--
作者：
Jia, Qian;Zhao, Xingquan;Wang, Yongjun
背景和目的-糖尿病（DM）是缺血性卒中的独立危险因素。然而，关于糖尿病对中国人群缺血性卒中预后的影响存在争议。我们在一项全国性的前瞻性登记研究--中国国家卒中登记研究中，调查了缺血性卒中患者发病后DM与死亡、依赖性和卒中复发之间的关系。方法--中国国家卒中登记研究连续招募了2007年至2008年因急性缺血性卒中住院的患者，并对这些患者的临床和功能结局进行了前瞻性随访（死亡、依赖性和中风复发）。多变量Logistic回归分析调整后的潜在混杂因素，包括年龄，性别，美国国立卫生研究院卒中量表评分，入院时的血糖水平，高血压，冠心病，吸烟，尿路感染，和其他factors.Results-DM和中风的结果之间的关联被确定在3483（27.0%）中风患者。与无糖尿病的卒中患者相比，糖尿病患者在卒中发作后3个月和6个月的死亡或依赖以及卒中复发的发生率显著较高。糖尿病是一个独立的危险因素死亡或依赖（调整后的比值比= 1.23，95%置信区间，1.10至1.37）缺血性卒中患者在发病后6个月onset.Conclusions-DM独立预测不良预后在中国患者急性缺血性卒中后。（中风。2011; 42：2758-2762.）
Background and Purpose-Diabetes mellitus (DM) is an independent risk factor for ischemic stroke. However, controversy exists with regard to the impact of DM on prognosis after ischemic stroke in the Chinese population. We investigated the associations between DM and death, dependency, and stroke recurrence in patients after ischemic stroke onset in a nationwide, prospective registry, the China National Stroke Registry.Methods-The China National Stroke Registry consecutively recruited patients hospitalized for acute ischemic stroke in 2007 to 2008 and who were prospectively followed up for clinical and functional outcomes (death, dependency, and stroke recurrence) at 3 and 6 months after disease onset. Multivariable logistic regression was performed to analyze the association between DM and stroke outcomes after adjusting for potential confounding including age, sex, National Institutes of Health Stroke Scale score, glucose level at admission, hypertension, coronary heart disease, smoking, urinary tract infection, and other factors.Results-DM was identified in 3483 (27.0%) of stroke patients. Compared with stroke patients without DM, patients with DM had a significantly higher incidence of death or dependency and of recurrent stroke at 3 and 6 months after stroke onset. DM was an independent risk factor for death or dependency (adjusted odds ratio = 1.23; 95% confidence interval, 1.10 to 1.37) in patients with ischemic stroke at 6 months after onset.Conclusions-DM independently predicted poor outcomes in Chinese patients after acute ischemic stroke. (Stroke. 2011; 42: 2758-2762.)