B-DNA Binding with Cobalt(III) and Vanadyl(2+) Derivatives of Tetracationic 5,10,15,20-Tetrakis(4-N-methylpyridyl)porphine: Combined CD, Optical, and Electronic MCD Spectra.
B-DNA Binding with Cobalt(III) and Vanadyl(2+) Derivatives of Tetracationic 5,10,15,20-Tetrakis(4-N-methylpyridyl)porphine: Combined CD, Optical, and Electronic MCD Spectra.
复制标题
B-DNA 与四阳离子 5,10,15,20-四(4-N-甲基吡啶基)卟啉的钴 (III) 和氧钒基 (2) 衍生物结合：组合 CD、光学和电子 MCD 光谱。
DOI：
10.1021/ic980349b
复制
发表时间：
1998
影响因子：
4.6
通讯作者：
A. F. Schreiner
中科院分区：
文献类型：
--
作者：
N. R. Barnes;A. F. Schreiner
电子MCD首次用于获得5,10,15,20-四（4- n -甲基吡啶基）卟啉六坐标CoIII和VO2+衍生物的自由态和dna结合态的电子和几何结构洞察。在卟啉Soret带（或B0）区域测量的MCD、CD和光谱与FLDr文献数据之间的相关性表明，每种金属卟啉在CT DNA的主槽中都具有正面取向，位点5‘AT3 ’和5‘CG3 ’优先，并且卟啉电偶极跃迁矩(edtms) μexD（结合卟啉中受扰动最大的方向）和μexD（受扰动最小的方向）的取向角为α/β/β ' = ~ 45°/180°/90°和~ 45°/180°/270°。分别。
Electronic MCD is used for the first time to obtain electronic and geometric structural insight into the free and DNA-bound states of the six-coordinate CoIII and VO2+ derivatives of 5,10,15,20-tetrakis(4-N-methylpyridyl)porphine. Correlations between MCD, CD, and optical spectra measured in the porphyrin Soret band (or B0) region, and FLDr literature data, are consistent with each metalloporphyrin having a face-on orientation in the major groove of CT DNA, sites 5‘AT3‘ and 5‘CG3‘ being preferred, and with porphyrin electric dipole transition moments (edtms) μexD (most perturbed direction in the bound porphyrin) and μexD (least perturbed) having orientation angles of α/β/β‘ = ∼45°/180°/90° and ∼45°/180°/270°, respectively.