Network pharmacology: a new approach for chinese herbal medicine research.
Network pharmacology: a new approach for chinese herbal medicine research.
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DOI：
10.1155/2013/621423
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Su SB
中科院分区：
文献类型：
--
作者：
Zhang GB;Li QY;Chen QL;Su SB
“一个基因、一个靶点、一种疾病”的主导范式影响了药物发现策略的许多方面。然而，近年来，人们已经认识到，许多有效的药物作用于多个靶点，而不是单个靶点。网络药理学是一个多学科的综合概念，它以系统生物学和多元药理学为基础，提供了一种“多靶点、多效应、复杂疾病”的新型网络模式，以“神枪”取代“灵丹妙药”。中草药已被公认为补充和替代医学的最重要策略之一。虽然社区卫生保健已经实施了很长时间，但其有效性和对公共卫生的有益贡献尚未得到充分认识。此外，对CHM公式的机制的知识是稀缺的。本文简要介绍了网络药理学的概念和意义。本文还讨论了网络药理学在中医药领域的应用和潜在作用，如数据收集、靶点预测、网络可视化、多组分相互作用和网络毒理学。此外，还对网络药理学的发展趋势进行了总结，并探讨了网络药理学在中药研究中的作用。
The dominant paradigm of “one gene, one target, one disease” has influenced many aspects of drug discovery strategy. However, in recent years, it has been appreciated that many effective drugs act on multiple targets rather than a single one. As an integrated multidisciplinary concept, network pharmacology, which is based on system biology and polypharmacology, affords a novel network mode of “multiple targets, multiple effects, complex diseases” and replaces the “magic bullets” by “magic shotguns.” Chinese herbal medicine (CHM) has been recognized as one of the most important strategies in complementary and alternative medicine. Though CHM has been practiced for a very long time, its effectiveness and beneficial contribution to public health has not been fully recognized. Also, the knowledge on the mechanisms of CHM formulas is scarce. In the present review, the concept and significance of network pharmacology is briefly introduced. The application and potential role of network pharmacology in the CHM fields is also discussed, such as data collection, target prediction, network visualization, multicomponent interaction, and network toxicology. Furthermore, the developing tendency of network pharmacology is also summarized, and its role in CHM research is discussed.