The effect of milk diet on lead metabolism in rats.
The effect of milk diet on lead metabolism in rats.
复制标题
牛奶饮食对大鼠铅代谢的影响。
DOI：
10.1016/0013-9351(73)90048-0
复制
发表时间：
1973
影响因子：
8.3
通讯作者：
K. Kostial
中科院分区：
文献类型：
--
作者：
D. Kello;K. Kostial
在四组6周龄雌性大鼠中研究了牛奶对铅吸收和保留的影响，这些大鼠在单次口服或腹腔内应用铅-203后。给动物喂食不同的饮食2周（放射性铅施用前1周和放射性铅施用后1周）。与正常饮食的对照大鼠相比，所有接受牛奶饮食或牛奶添加剂的动物显示出较高的脂肪和蛋白质摄入量以及较低的碳水化合物、维生素D和铁摄入量。钙、磷酸盐和热量的摄入量在所有组中大致相同。口服铅-203的身体保留在牛奶饮食的动物中要高得多（在正常饮食和牛奶的大鼠中高出4倍;在牛奶的动物中高出57倍;在奶粉的大鼠中高出33倍）。牛奶饮食对腹腔注射后铅-203的全身滞留只有轻微的影响（在大鼠中，牛奶和奶粉分别高出1.3倍和1.2倍），这表明牛奶主要通过大大增加肠道对铅的吸收而显著增强铅在体内的滞留。
The effect of milk on lead absorption and retention was studied in four groups of 6-wk-old female rats after a single oral or intraperitoneal application of lead-203. The animals were fed different diets for 2 wk (1 wk prior and 1 wk after the radiolead application). All animals receiving milk diet or milk additives showed a higher intake of fats and proteins and a lower intake of carbohydrates, vitamin D, and iron than control rats fed on normal diet. The calcium, phosphate, and calorie intake was about the same in all groups.The body retention of the orally applied lead-203 was much higher in animals on milk diet (4 times higher in rats on normal diet and cow's milk; 57 in animals on cow's milk; 33 times in rats on powdered milk) than in controls. The milk diet had only a slight effect on the whole body retention of lead-203 after intraperitoneal application (1.3 and 1.2 times higher in rats on cow's and powdered milk, respectively).This indicates that milk causes considerable enhancement of lead retention in the body mainly by greatly increasing its absorption from the intestinal tract.