Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers
Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers
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DOI：
10.1159/000369495
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发表时间：
2015-01-01
期刊：
影响因子：
3.5
通讯作者：
Dosaka-Akita, Hirotoshi
中科院分区：
文献类型：
--
作者：
Honma, Rio;Kinoshita, Ichiro;Dosaka-Akita, Hirotoshi
目的：聚焦转移酶8 （FUT8）是唯一负责糖蛋白中天冬酰胺连接寡糖的核心α 1,6-聚焦化的酶，是癌症发生和进展的重要酶。我们检测了FUT8在非小细胞肺癌（nsclc）中的表达，分析其临床意义。我们还检测了鸟苷二磷酸-甘露糖-4,6-脱水酶（GMD）的表达，这是合成集中寡糖的必要条件。方法：采用免疫组织化学方法，我们评估了FUT8和GMD的表达与潜在治愈性非小细胞肺癌患者生存和预后的关系。结果：FUT8在129例非小细胞肺癌中高表达67例（51.9%），在非鳞状细胞癌中显著表达（p = 0.008）。FUT8的高表达与生存率低相关（p = 0.03），也是潜在治愈性非小细胞肺癌患者的一个重要且独立的不利预后因素（p = 0.047）。GMD高表达与FUT8高表达显著相关（p = 0.04）。结论：FUT8高表达与潜在治愈性非小细胞肺癌切除术患者的不良临床结果相关，提示FUT8可能是预后因素之一。分析FUT8及其核心聚焦产物的表达可能为非小细胞肺癌的治疗靶点提供新的见解。(C) 2015 S. Karger AG，巴塞尔
Objecitive: Fucosyltransferase 8 (FUT8), the only enzyme responsible for the core alpha 1,6-fucosylation of asparagine-linked oligosaccharides of glycoproteins, is a vital enzyme in cancer development and progression. We examined FUT8 expression in non-small cell lung cancers (NSCLCs) to analyze its clinical significance. We also examined the expression of guanosine diphosphate-mannose-4,6-dehydratase (GMD), which is imperative for the synthesis of fucosylated oligosaccharides. Methods: Using immunohistochemistry, we evaluated the expression of FUT8 and GMD in relation to patient survival and prognosis in potentially curatively resected NSCLCs. Results: High expression of FUT8 was found in 67 of 129 NSCLCs (51.9%) and was significantly found in non-squamous cell carcinomas (p = 0.008). High expression of FUT8 was associated with poor survival (p = 0.03) and was also a significant and independent unfavorable prognostic factor in patients with potentially curatively resected NSCLCs (p = 0.047). High expression of GMD was significantly associated with high FUT8 expression (p = 0.04). Conclusions: High expression of FUT8 is associated with an unfavorable clinical outcome in patients with potentially curatively resected NSCLCs, suggesting that FUT8 can be a prognostic factor. The analysis of FUT8 expression and its core fucosylated products may provide new insights for the therapeutic targets of NSCLCs. (C) 2015 S. Karger AG, Basel