Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity
Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity
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DOI：
10.1016/j.fitote.2007.07.001
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发表时间：
2008-01-01
期刊：
影响因子：
3.4
通讯作者：
Xu, Li-zhen
中科院分区：
文献类型：
--
作者：
An, Ning;Zou, Zhong-mei;Xu, Li-zhen
从高良姜的根茎中分离出两种新的二芳基庚烷类化合物 (1, 2) 以及两种已知的类似物 (3, 4)。根据光谱分析，新化合物被阐明为 (5S)-5-羟基-7-(3, 4-二羟基苯基)-1-苯基-3-庚酮 (1) 和 (5R)-5-羟基-7-(3-甲氧基-4, 5-二羟基苯基)-1-苯基-3-庚酮 (2)。化合物4对人肿瘤细胞系HepG2、MCF-7和SF-268表现出中等的细胞毒性，而化合物1-3没有发现显着效果。 (c) 2007 Elsevier B.V. 保留所有权利。
Two new diarylheptanoids (1, 2), together with two known analogs (3, 4), were isolated from the rhizomes of Alpinia officinarum. The new compounds were elucidated to be (5S)-5-hydroxy-7-(3, 4-dihydroxyphenyl)-l-phenyl-3-heptanone (1) and (5R)-5-hydroxy-7-(3-methoxy-4, 5-dihydroxyphenyl)-l-phenyl-3-heptanone (2) based on their spectral analysis. Compound 4 showed moderate cytotoxicity against human tumor cell lines, HepG2, MCF-7 and SF-268, while no significant effect were found for compounds 1-3. (c) 2007 Elsevier B.V. All rights reserved.