BEHAVIORAL SENSITIZATION AND RELATIVE HYPERRESPONSIVENESS OF STRIATAL AND LIMBIC DOPAMINERGIC-NEURONS AFTER REPEATED METHAMPHETAMINE TREATMENT
BEHAVIORAL SENSITIZATION AND RELATIVE HYPERRESPONSIVENESS OF STRIATAL AND LIMBIC DOPAMINERGIC-NEURONS AFTER REPEATED METHAMPHETAMINE TREATMENT
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DOI：
10.1016/0014-2999(83)90006-7
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发表时间：
1983-01-01
影响因子：
5
通讯作者：
TORU, M
中科院分区：
文献类型：
--
作者：
NISHIKAWA, T;MATAGA, N;TORU, M
大鼠被用于研究重复甲基苯丙胺治疗对刻板行为和纹状体和边缘多巴胺代谢的影响，以响应药物或其他多巴胺激动剂的挑战。重复给予d-甲基苯丙胺（每天6 mg/kg，持续3-14天）不仅对化合物（停药后44-89天）而且对阿扑吗啡和诺米芬辛产生长期行为敏化（对激发注射的反应增强）。甚至单次注射d-甲基苯丙胺（6 mg/kg）也能增强对药物的行为反应。激发剂量的d-甲基苯丙胺（2 mg/kg）显著增加了致敏动物纹状体和中脑边缘区的多巴胺周转率（较低的多巴胺和较高的3，4-二羟基苯乙酸水平，3，4-二羟基苯乙酸与多巴胺的比率较高），在第15天停止使用药物（6 mg/kg/天）重复治疗14天。甲基苯丙胺诱导的行为敏化明显伴随着中枢多巴胺能传递的增加。
Rats were used in a study of the effects of repeated methamphetamine treatment on stereotyped behavior and striatal and limbic dopamine metabolism in response to challenge with the drug or other dopamine agonists. Repeated administration of d-methamphetamine (6 mg/kg per day for 3-14 days) produced long-term behavioral sensitization (augmented response to a challenge injection) not only to the compound (at 44-89 days after drug withdrawal) but also to apomorphine and nomifensine. Even a single injection of d-methamphetamine (6 mg/kg) enhanced the behavioral response to the drug. A challenge dose of d-methamphetamine (2 mg/kg) markedly increased dopamine turnover (lower dopamine and higher 3,4-dihydroxyphenylacetic acid levels, higher ratios of 3,4-dihydroxyphenylacetic acid over dopamine) in the striatum and mesolimbic area of the sensitized animals on day 15 of withdrawal from treatment repeated for 14 days with the drug (6 mg/kg per day). Behavioral sensitization induced by methamphetamine is evidently accompanied by increased central dopaminergic transmission.