Improving Personalized Structure to Function Mapping From Optic Nerve Head to Visual Field.
Improving Personalized Structure to Function Mapping From Optic Nerve Head to Visual Field.
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DOI：
10.1167/tvst.10.1.19
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发表时间：
2021-01
影响因子：
3
通讯作者：
McKendrick AM
中科院分区：
文献类型：
--
作者：
Turpin A;McKendrick AM
需要地图将视野位置与视神经乳头区域相关联。我们比较个性化的结构到功能映射（自定义映射）的人口衍生的映射模式（POP-MAP）。对118只患眼的地图进行了比较，这些患眼具有昏迷性视野丧失、使用谱域光学相干断层扫描（OCT）测量的视乳头周围视网膜神经纤维层（cpRNFL）厚度以及两个标志：视神经乳头（ONH）相对于中央凹的位置和颞中缝角。视野损伤的位置（总偏差<-6 dB）被映射到以每个映射方案给定的角度为中心的30° ONH扇区。对于不同的cpRNFL损伤概率水平，确定每个位置的受损功能和受损结构之间的一致性，一致性位置的数量除以受损区域位置的总数，得到每只眼睛的一致性比率。对于最严格的一致性标准（最小cpRNFL厚度<正常值的1%），CUSTOM-MAP的平均一致率高于POP-MAP（60.5% c.f. 57.0%配对Wilcoxon，P = 0.005），其中CUSTOM-MAP在43只眼中具有更高的比率，POP-MAP在21只眼中具有更高的比率。对于所有cpRNFL概率水平<正常值的20%，CUSTOM-MAP比POP-MAP一致的位置更多。检查差异的空间模式显示，CUSTOM-MAP通常在弓形区域表现更好，而POP-MAP的益处低于黄斑。个体化结构-功能映射所需的解剖参数很容易用OCT测量，并且可以为某些眼睛提供更好的一致性。个性化的结构-功能映射可以提高这些措施之间的一致性。我们提供了一个基于网络的工具来创建定制的地图。
Maps are required to relate visual field locations to optic nerve head regions. We compare individualized structure-to-function mapping (CUSTOM-MAP) to a population-derived mapping schema (POP-MAP). Maps were compared for 118 eyes with glaucomatous field loss, circumpapillary retinal nerve fiber layer (cpRNFL) thickness measured using spectral domain optical coherence tomography (OCT), and two landmarks: the optic nerve head (ONH) position relative to the fovea and the temporal raphe angle. Locations with visual field damage (total deviation < −6 dB) were mapped to 30° ONH sectors centered on the angle given by each mapping schema. The concordance between damaged function and damaged structure was determined per location for various cpRNFL damage probability levels, with the number of concordant locations divided by the total number of damaged field locations providing a concordance ratio per eye. For the strictest concordance criteria (minimum cpRNFL thickness < 1% of normal), CUSTOM-MAP had higher mean concordance ratio than POP-MAP (60.5% c.f. 57.0% paired Wilcoxon, P = 0.005), with CUSTOM-MAP having a higher ratio in 43 eyes and POP-MAP having a higher ratio in 21 eyes. For all cpRNFL probability levels <20% of normal, more locations concorded for CUSTOM-MAP than POP-MAP. Inspection of the spatial patterns of differences revealed that CUSTOM-MAP often performed better in the arcuate regions, whereas POP-MAP had benefits inferior to the macula. Anatomic parameters required for individualized structure-function mapping are readily measured with OCT and can provide improved concordance for some eyes. Personalizing structure-function mapping may improve concordance between these measures. We provide a web-based tool for creating customized maps.