Atrial natriuretic peptide levels during development of chronic heart failure after myocardial infarction in rats.
Atrial natriuretic peptide levels during development of chronic heart failure after myocardial infarction in rats.
复制标题
大鼠心肌梗死后慢性心力衰竭发展过程中心房钠尿肽水平。
DOI：
10.1016/0024-3205(87)90294-3
复制
发表时间：
1987
期刊：
影响因子：
6.1
通讯作者：
Goldman,S
中科院分区：
文献类型：
--
作者：
Lee,RW;Gay,RG;Moffett,C;Johnson,DG;Goldman,S
慢性心力衰竭患者血清心钠素(ANP)水平升高，可能是由于心内压升高导致左心房扩张所致。为了明确血清ANP水平变化的时程，并确定其与左心室舒张末压的关系，采用冠状动脉结扎的方法造成大鼠心肌梗死和左心衰。随后4周每周测量心钠素水平。在心肌梗死和左室舒张末压升高的大鼠中，ANP水平在第7天和第14天没有变化。然而，在第21天和第28天，ANP水平升高了3倍以上。心钠素水平与左心室舒张末压之间存在相关性。血浆ANP水平与右房压、血钠浓度无相关性。我们的结论是，心肌梗死后左室舒张末压的慢性升高需要产生心钠素的增加，从而导致慢性心力衰竭。
Serum levels of atrial natriuretic peptide (ANP) are elevated in chronic heart failure presumably due to dilatation of the left atrium resulting from increases in intracardiac pressures. To define the time course of changes in serum ANP levels and to determine the relationship to left ventricular end-diastolic pressure, rats were subjected to coronary artery ligation to produce myocardial infarction and left ventricular failure. Atrial natriuretic peptide levels were measured weekly for four weeks thereafter. In rats with myocardial infarction and elevation of left ventricular end-diastolic pressure there was no change in ANP levels at 7 and 14 days. However, at day 21 and 28, ANP levels were elevated more than 3 fold. There was a correlation between ANP levels and left ventricular end-diastolic pressures. There was no correlation between ANP levels and right atrial pressures or serum sodium concentrations. We conclude that the chronic elevation of left ventricular end-diastolic pressure is required to produce an increase in ANP after myocardial infarction which results in chronic heart failure.