Yin Yang 1 directly regulates the transcription of RE-1 silencing transcription factor
Yin Yang 1 directly regulates the transcription of RE-1 silencing transcription factor
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DOI：
10.1002/jnr.21595
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发表时间：
2008-05-01
影响因子：
4.2
通讯作者：
Fei, Jian
中科院分区：
文献类型：
--
作者：
Jiang, Lichun;Yao, Minghui;Fei, Jian
RE-1沉默转录因子(REST)是一种主要的转录因子，在胚胎发育，特别是在神经发生和神经可塑性过程中发挥着关键作用。然而，REST基因转录调控的机制仍是一个悬而未决的问题。在此，我们通过生物信息学分析和实验研究相结合的方法，报道了转录因子阴阳1(YY1)结合到小鼠REST基因启动子中一个保守的YY1结合部位，并正调控该启动子在SH-SY5Y细胞中的活性。此外，对微阵列数据的分析表明，YY1和REST基因的表达之间存在显著的相关性。总体而言，本研究表明YY1直接调控REST基因的表达。(C)2007年Wiley-Liss，Inc.
The RE-1 silencing transcription factor (REST) is a master transcription factor that plays a critical role in embryo development, especially during the process of neurogenesis and neural plasticity. However, the mechanism of REST gene transcription regulation is still an open question. Here, by combining bioinformatics analysis and experimental studies, we report that the transcription factor Yin Yang 1 (YY1) bound to a conserved YY1 binding site in the promoter of the mouse REST gene and positively regulated activity of this promoter in SH-SY5Y cells. Furthermore, analysis of microarray data revealed a significant correlation between the expression of YY1 and REST genes. Overall, this study suggests that YY1 directly regulates expression of the REST gene. (C) 2007 Wiley-Liss, Inc.